U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pot1 shelterin complex subunit Pot1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542703, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pot1
    Official Full Name
    shelterin complex subunit Pot1
    Primary source
    PomBase:SPAC26H5.06
    Locus tag
    SPOM_SPAC26H5.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pot1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4129224..4132350)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Gid5 Neighboring gene ncRNA Neighboring gene IPT/TIG ankyrin repeat-containing transcription regulator Neighboring gene ncRNA Neighboring gene seven transmembrane receptor protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Exploring Genetic Interactions with Telomere Protection Gene pot1 in Fission Yeast. Ueno M. Biomolecules, 2023 Feb 15. PMID 36830739, Free PMC Article
    2. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Lei M, et al. Biochemistry, 2002 Dec 10. PMID 12463756
    3. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Lei M, et al. Nature, 2003 Nov 13. PMID 14614509
    4. Extended DNA binding site in Pot1 broadens sequence specificity to allow recognition of heterogeneous fission yeast telomeres. Trujillo KM, et al. J Biol Chem, 2005 Mar 11. PMID 15637058
    5. A new model for Schizosaccharomyces pombe telomere recognition: the telomeric single-stranded DNA-binding activity of Pot11-389. Croy JE, et al. J Mol Biol, 2006 Aug 4. PMID 16842820

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast.
      Title: Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast.
    2. Exploring Genetic Interactions with Telomere Protection Gene pot1 in Fission Yeast.
      Title: Exploring Genetic Interactions with Telomere Protection Gene pot1 in Fission Yeast.
    3. The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
      Title: The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
    4. Study shows that The C-terminal domain of the DNA-binding domain, Pot1pC, exhibits non-specific ssDNA recognition and discriminates against RNA by utilizing non-compensatory binding modes that feature significant rearrangement of the binding interface.
      Title: Discrimination against RNA Backbones by a ssDNA Binding Protein.
    5. Thus, our results suggest that pik1(+) is required for the maintenance of circular chromosomes.
      Title: Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1.
    6. The conservation between fission yeast Tpz1-Pot1 and human TPP1-POT1 interactions resulted in mapping a human melanoma-associated POT1 mutation (A532P) to the TPP1-POT1 interface.
      Title: Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.
    7. Long G2 phase of pot1-rqh1 double mutant may allow time for the accumulation of recombination intermediates which disturb chromosome segregation and make cells sensitive to thiabendazole.
      Title: Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.
    8. The Pot1 DNA-binding domain is capable of binding DNA in at least two structurally distinct binding modes.
      Title: The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3' end availability.
    9. Pot1 promiscuity is implemented through binding modes that thermodynamically compensate for base-substitutions through alternate stacking interactions and hydrogen-bonding networks.
      Title: Nonspecific recognition is achieved in Pot1pC through the use of multiple binding modes.
    10. Results indicate an unanticipated ssDNA-binding mode in which two SpPot1 molecules bind an oligonucleotide containing two telomeric repeats.
      Title: DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-rich strand telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables telomerase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of nuclear telomere cap complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    part_of shelterin complex IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of telomere cap complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    shelterin complex subunit Pot1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4129224..4132350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019882.3 → NP_594453.1  shelterin complex subunit Pot1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594453.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13988
      Conserved Domains (2) summary
      smart00976
      Location:27 → 171
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16686
      Location:203 → 336
      POT1PC; ssDNA-binding domain of telomere protection protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous