U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cid1 terminal uridylyltransferase Cid1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542420, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cid1
    Official Full Name
    terminal uridylyltransferase Cid1
    Primary source
    PomBase:SPAC19D5.03
    Locus tag
    SPOM_SPAC19D5.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cid1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (5206580..5208422)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein tyrosine phosphatase Pyp2 Neighboring gene ncRNA Neighboring gene protein Emc10 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity. Yates LA, et al. Nucleic Acids Res, 2015 Mar 11. PMID 25712096, Free PMC Article
    2. A critical switch in the enzymatic properties of the Cid1 protein deciphered from its product-bound crystal structure. Munoz-Tello P, et al. Nucleic Acids Res, 2014 Mar. PMID 24322298, Free PMC Article
    3. Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP selectivity. Lunde BM, et al. Nucleic Acids Res, 2012 Oct. PMID 22885303, Free PMC Article
    4. Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase. Yates LA, et al. Nat Struct Mol Biol, 2012 Aug. PMID 22751018, Free PMC Article
    5. The Cid1 poly(U) polymerase. Rissland OS, et al. Biochim Biophys Acta, 2008 Apr. PMID 18371314

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that a hinge region (N164-N165) of terminal uridylyltransferase Cid1 is essential for catalytic activity.
      Title: Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.
    2. Structural analysis of Cid1 bound to a non-hydrolyzable nucleotide UMPNPP and bound to its minimal pseudo-product ApU revealed new key residues for the substrate/product recognition.
      Title: A critical switch in the enzymatic properties of the Cid1 protein deciphered from its product-bound crystal structure.
    3. This work demonstrates that Cid1 is able to accommodate all 4 tested ribonucleotide triphosphates (NTP) in the active site, but there are differences in recognition that suggest UTP is the preferred NTP.
      Title: Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP selectivity.
    4. describe crystal structures of cytoplasmic terminal uridylyl transferase Cid1 in apo conformers and bound to UTP, and demonstrate that a single histidine residue, conserved in mammalian Cid1 orthologs, is responsible for discrimination between UTP and ATP
      Title: Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase.
    5. Cid1 RNA binding properties, a feature with critical implications for miRNAs, histone mRNAs, and, more generally, cellular RNA degradation
      Title: Functional implications from the Cid1 poly(U) polymerase crystal structure.
    6. The Schizosaccharomyces pombe cytoplasmic protein Cid1 acts as a poly(U) polymerase (PUP). Polyadenylated actin mRNA, a target of this activity, is uridylated upon arrest in S phase and is likely to be one of many such Cid1 targets
      Title: The Cid1 poly(U) polymerase.
    7. Results describe the biochemical activity of fission yeast Schizosaccharomyces pombe Cid1, a putative cytoplasmic poly(A) polymerase implicated in cell cycle checkpoint controls.
      Title: Efficient RNA polyuridylation by noncanonical poly(A) polymerases.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA uridylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables UTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyuridylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    terminal uridylyltransferase Cid1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5206580..5208422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020330.3 → NP_594901.1  terminal uridylyltransferase Cid1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594901.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13833, O94608
      Conserved Domains (1) summary
      COG5260
      Location:1 → 405
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials