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    swi3 replication fork protection complex subunit Swi3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361323, updated on 18-Sep-2024

    Summary

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    Official Symbol
    swi3
    Official Full Name
    replication fork protection complex subunit Swi3
    Primary source
    PomBase:SPBC30D10.04
    Locus tag
    SPOM_SPBC30D10.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See swi3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (3090859..3091856, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene biotin-protein ligase Neighboring gene U6 snRNP-associated protein Lsm4 Neighboring gene ncRNA Neighboring gene sepiapterin reductase Neighboring gene chaperone protein Mzm1 Neighboring gene ncRNA Neighboring gene IMP 5'-nucleotidase Neighboring gene ncRNA Neighboring gene transcription corepressor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching. Vengrova S, et al. Genes Dev, 2004 Apr 1. PMID 15059961, Free PMC Article
    2. Biochemical interactions between proteins and mat1 cis-acting sequences required for imprinting in fission yeast. Lee BS, et al. Mol Cell Biol, 2004 Nov. PMID 15509785, Free PMC Article
    3. Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity. Noguchi C, et al. PLoS One, 2012. PMID 22952839, Free PMC Article
    4. Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1. Tanaka T, et al. J Biol Chem, 2010 Dec 17. PMID 20924116, Free PMC Article
    5. swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe. Dalgaard JZ, et al. Cell, 2000 Sep 15. PMID 11030618

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
      Title: Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
    2. RFC(Ctf18) and the Swi1-Swi3 complex function in separate and redundant pathways essential for replication fork stabilization to facilitate sister chromatid cohesion in fission yeast.
      Title: RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.
    3. Hsk1-Dfp1/Him1 and Swi1-Swi3 complexes have interrelated roles in stabilization of arrested replication forks
      Title: Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Y-form DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gene conversion at mating-type locus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating-type locus imprinting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest at mating type locus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in replication fork processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    replication fork protection complex subunit Swi3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3090859..3091856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022202.3 → NP_001018832.1  replication fork protection complex subunit Swi3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_001018832.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14350, Q6IUU5
      Conserved Domains (1) summary
      pfam07962
      Location:53 → 131
      Swi3; Replication Fork Protection Component Swi3
    Nucleotide Protein
    Heading Accession and Version

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