UBX2 Ubx2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UBX2
Official Full Name: Ubx2p
Primary source: SGD:S000004475
Locus tag: YML013W
See related: AllianceGenome:SGD:S000004475; FungiDB:YML013W; VEuPathDB:YML013W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SEL1
Summary: Enables protein-macromolecule adaptor activity. Involved in lipid droplet organization; mitochondrial protein processing; and proteasomal protein catabolic process. Located in endoplasmic reticulum membrane; lipid droplet; and plasma membrane. Part of Doa10p ubiquitin ligase complex and Hrd1p ubiquitin ligase ERAD-L complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See UBX2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (244149..245903)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of ERAD bridging factor UBX2 modulates lipid metabolism and leads to ER stress-associated apoptosis during cadmium toxicity in Saccharomyces cerevisiae.
Title: Loss of ERAD bridging factor UBX2 modulates lipid metabolism and leads to ER stress-associated apoptosis during cadmium toxicity in Saccharomyces cerevisiae.
A AAA ATPase Cdc48 with a cofactor Ubx2 facilitates ubiquitylation of a mitochondrial fusion-promoting factor Fzo1 for proteasomal degradation.
Title: A AAA ATPase Cdc48 with a cofactor Ubx2 facilitates ubiquitylation of a mitochondrial fusion-promoting factor Fzo1 for proteasomal degradation.
Recent work has unveiled a pathway similar to endoplasmic-reticulum-associated degradation in fine-tuning the fidelity of translocase of the outer mitochondrial membrane complex-mediated mitochondrial import by Ubx2. [review]
Title: Beyond ER: Regulating TOM-Complex-Mediated Import by Ubx2.
The results indicated that two different Ubp3 and Ubx2 complexes independently regulate mitochondrial fusion and Fzo1 turnover.
Title: Two Cdc48 cofactors Ubp3 and Ubx2 regulate mitochondrial morphology and protein turnover.
UBX domain-containing proteins are involved in lipid homeostasis and stress responses
Title: UBX domain-containing proteins are involved in lipid homeostasis and stress responses in Pichia pastoris.
Ubx2 is a key player in the regulation of membrane lipid biosynthesis.
Title: Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.
The human Ubxd8 complements the defect of ubx2Delta in Saccharomyces cerevisiae.
Title: The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis.
Operates in the endoplasmic reticulum-associated degradation pathway by coupling Cdc48p to ER membranes.
Title: Sel1p/Ubx2p participates in a distinct Cdc48p-dependent endoplasmic reticulum-associated degradation pathway.
Data suggest that Shp1 and Ubx2 are adaptors for Cdc48-dependent protein degradation through the ubiquitin/proteasome pathway.
Title: Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERAD pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in lipid droplet organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondria-associated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Doa10p ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Hrd1p ubiquitin ligase ERAD-L complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ubx2p

NP_013699.1

Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis; required for mitochondrial protein translocation-associated degradation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

244149..245903

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182371.1 → NP_013699.1 TPA: Ubx2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013699.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZG1, Q04228

UniProtKB/TrEMBL

A6ZM49, N1P5A1

Conserved Domains (2) summary

pfam14555
Location:19 → 61

UBA_4; UBA-like domain

cl28922
Location:431 → 570

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold