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    pek1 MAP kinase kinase Pek1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540919, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pek1
    Official Full Name
    MAP kinase kinase Pek1
    Primary source
    PomBase:SPBC543.07
    Locus tag
    SPOM_SPBC543.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mkk1; skh1
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    Genomic context

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    See pek1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (4312443..4314140)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Dbp8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CoA pyrophosphatase (FIT) family lipid storage protein Neighboring gene ncRNA Neighboring gene m-AAA protease Yta12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe. Loewith R, et al. J Cell Sci, 2000 Jan. PMID 10591634
    2. Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast. Vázquez B, et al. Cell Signal, 2015 Dec. PMID 26432170
    3. Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe. Madrid M, et al. J Biol Chem, 2006 Jan 27. PMID 16291757
    4. The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch. Sugiura R, et al. Nature, 1999 Jun 3. PMID 10365961
    5. Feedback regulation of MAPK signalling by an RNA-binding protein. Sugiura R, et al. Nature, 2003 Aug 21. PMID 12931193

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell integrity MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell integrity MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell wall organization or biogenesis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    MAP kinase kinase Pek1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4312443..4314140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023815.3 → NP_596795.1  MAP kinase kinase Pek1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596795.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UUK6, Q9Y884
      Conserved Domains (2) summary
      cd06621
      Location:77 → 361
      PKc_Pek1_like; Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases
      pfam00069
      Location:85 → 343
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version

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