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    ERV2 flavin-linked sulfhydryl oxidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856152, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERV2
    Official Full Name
    flavin-linked sulfhydryl oxidase
    Primary source
    SGD:S000006241
    Locus tag
    YPR037C
    See related
    AllianceGenome:SGD:S000006241; FungiDB:YPR037C; VEuPathDB:YPR037C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables flavin-dependent sulfhydryl oxidase activity. Involved in regulation of protein folding in endoplasmic reticulum. Located in fungal-type vacuole membrane. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERV2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (646448..647038, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit H Neighboring gene Spo24p Neighboring gene Irc16p Neighboring gene Tip41p Neighboring gene translation initiation factor eIF5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p. Gross E, et al. Nat Struct Biol, 2002 Jan. PMID 11740506
    2. Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase. Wang W, et al. Biochemistry, 2007 Mar 20. PMID 17298084, Free PMC Article
    3. Flavin-linked Erv-family sulfhydryl oxidases release superoxide anion during catalytic turnover. Daithankar VN, et al. Biochemistry, 2012 Jan 10. PMID 22148553, Free PMC Article
    4. Structural determinants of substrate access to the disulfide oxidase Erv2p. Vala A, et al. J Mol Biol, 2005 Dec 9. PMID 16288914
    5. Identification and characterisation of eroA and ervA, encoding two putative thiol oxidases from Aspergillus niger. Harvey AR, et al. Gene, 2010 Aug 1. PMID 20438816

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiol oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of protein folding in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flavin-linked sulfhydryl oxidase
    NP_015362.1
    • Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      646448..647038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184134.1 → NP_015362.1  TPA: flavin-linked sulfhydryl oxidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015362.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W448, Q12284
      UniProtKB/TrEMBL
      A6ZWT1, B3LL99, B5VTJ5, C7GQA0, C8ZJ62, G2WPL6, N1NW13
      Conserved Domains (1) summary
      COG5054
      Location:1 → 180
      ERV1; Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12284.1

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