rif1 telomere length regulator Rif1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: rif1
Official Full Name: telomere length regulator Rif1
Primary source: PomBase:SPAC6F6.17
Locus tag: SPOM_SPAC6F6.17
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: SPAPJ736.01; tap1; tap11
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Genomic context

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See rif1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (2766273..2770704)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect.
Title: Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect.
Results illustrate functional domains of Rif1 and indicate importance of both the N-terminal HEAT repeat segment and C-terminal G4 binding/oligomerization domain as well as other functionally unassigned segments of Rif1 in regulation of origin firing.
Title: Both a Unique Motif at the C Terminus and an N-Terminal HEAT Repeat Contribute to G-Quadruplex Binding and Origin Regulation by the Rif1 Protein.
The higher-order structure generated at Rif1 binding sequence involved both DNA strands, and in some cases, G4s may form on both of these strands.
Title: Molecular architecture of G-quadruplex structures generated on duplex Rif1-binding sequences.
Genetic screens for identifying cis- and trans-acting factors creating heterochromatin-euchromatin boundaries showed unexpected properties for Rif1 and Taz1. Most cis-acting elements identified came from genomic loci bound by Taz1 and associated with origins of replication repressed by Taz1 and Rif1. Boundary formation by these elements required Taz1 and Rif1 and coincided with altered replication timing.
Title: Establishment of expression-state boundaries by Rif1 and Taz1 in fission yeast.
Rif1 is a critical determinant of the origin activation program on the fission yeast chromosomes [Rif1] [strain not found in database]
Title: Rif1 is a global regulator of timing of replication origin firing in fission yeast.
Rif1 localizes to the anaphase mid-region and regulates the resolution of persisting DNA structures.
Title: Rif1 Regulates the Fate of DNA Entanglements during Mitosis.
These results suggest that Rif1 recognizes and binds G quadruplex-like structures at selected intergenic regions, thus generating local chromatin structures that may exert long-range suppressive effects on origin firing.
Title: Rif1 binds to G quadruplexes and suppresses replication over long distances.
Rap1 and Rif1 are each required for a subset of the functions of Taz1
Title: Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables G-quadruplex DNA binding	EXP Inferred from Experiment more info	PubMed
enables chromatin-protein adaptor activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome, telomeric repeat region	IBA Inferred from Biological aspect of Ancestor more info
is_active_in chromosome, telomeric repeat region	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	HDA more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: telomere length regulator Rif1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

2766273..2770704

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019340.3 → NP_593910.2 telomere length regulator Rif1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593910.2

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O14247, Q96UP3, Q9P7P5

Conserved Domains (2) summary

NF000535
Location:1128 → 1282

MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

pfam12231
Location:119 → 471

Rif1_N; Rap1-interacting factor 1 N terminal