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    hmt1 vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Hmt1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361134, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hmt1
    Official Full Name
    vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Hmt1
    Primary source
    PomBase:SPCC737.09c
    Locus tag
    SPOM_SPCC737.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPCC74.08c
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    Genomic context

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    See hmt1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1914756..1917671, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene midasin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene rrm type RNA-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter. Ortiz DF, et al. EMBO J, 1992 Oct. PMID 1396551, Free PMC Article
    2. Transport of metal-binding peptides by HMT1, a fission yeast ABC-type vacuolar membrane protein. Ortiz DF, et al. J Biol Chem, 1995 Mar 3. PMID 7876244
    3. A common highly conserved cadmium detoxification mechanism from bacteria to humans: heavy metal tolerance conferred by the ATP-binding cassette (ABC) transporter SpHMT1 requires glutathione but not metal-chelating phytochelatin peptides. Prévéral S, et al. J Biol Chem, 2009 Feb 20. PMID 19054771
    4. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. Sooksa-Nguan T, et al. J Biol Chem, 2009 Jan 2. PMID 19001374
    5. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. Mendoza-Cózatl DG, et al. J Biol Chem, 2010 Dec 24. PMID 20937798, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification in Schizosaccharomyces pombe and Caenorhabditis elegans.
      Title: The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification.
    2. SpHMT1 confers cadmium tolerance in the absence of phytochelatins but depending on the presence of GSH and ATP.
      Title: A common highly conserved cadmium detoxification mechanism from bacteria to humans: heavy metal tolerance conferred by the ATP-binding cassette (ABC) transporter SpHMT1 requires glutathione but not metal-chelating phytochelatin peptides.
    3. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration.
      Title: Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ABC-type phytochelatin transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cadmium ion import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular detoxification of cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione transmembrane import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phytochelatin 2 import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phytochelatin import into vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Hmt1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1914756..1917671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023362.4 → NP_588371.3  vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Hmt1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588371.3

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13675, Q02592, Q9UQW7, Q9USI3
      Conserved Domains (3) summary
      cd03253
      Location:584 → 820
      ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C
      COG5265
      Location:324 → 819
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
      pfam00664
      Location:269 → 538
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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