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    SPC2 signal peptidase complex subunit SPC2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPC2
    Official Full Name
    signal peptidase complex subunit SPC2
    Primary source
    SGD:S000004519
    Locus tag
    YML055W
    See related
    AllianceGenome:SGD:S000004519; FungiDB:YML055W; VEuPathDB:YML055W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SPY1
    Summary
    Contributes to peptidase activity. Involved in negative regulation of post-translational protein targeting to membrane, translocation; protein targeting to ER; and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPC2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (164790..165326)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene calcineurin catalytic subunit A Neighboring gene IMP dehydrogenase IMD4 Neighboring gene ncRNA Neighboring gene L-lactate dehydrogenase (cytochrome) Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity. Meyer HA, et al. J Biol Chem, 1997 May 16. PMID 9148931
    2. Yeast signal peptidase contains a glycoprotein and the Sec11 gene product. YaDeau JT, et al. Proc Natl Acad Sci U S A, 1991 Jan 15. PMID 1846444, Free PMC Article
    3. Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. Mullins C, et al. J Biol Chem, 1996 Nov 15. PMID 8910564
    4. In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum. Fang H, et al. J Biol Chem, 1997 May 16. PMID 9148930
    5. Identification of yeast proteins necessary for cell-surface function of a potassium channel. Haass FA, et al. Proc Natl Acad Sci U S A, 2007 Nov 13. PMID 17989219, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of post-translational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to ER IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal peptidase complex subunit SPC2
    NP_013657.1
    • Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; inhibits SRP-independent translocation into the ER with STE24; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      164790..165326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182413.1 → NP_013657.1  TPA: signal peptidase complex subunit SPC2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZB9, Q04969
      UniProtKB/TrEMBL
      A6ZM11, B3LLK1, B5VP75, C7GME8, C8ZEF2, G2WK01, N1P686
      Conserved Domains (1) summary
      pfam06703
      Location:20 → 170
      SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04969.1

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