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    nrd1 RNA-binding protein Nrd1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541755, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nrd1
    Official Full Name
    RNA-binding protein Nrd1
    Primary source
    PomBase:SPAC2F7.11
    Locus tag
    SPOM_SPAC2F7.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    msa2
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    Genomic context

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    See nrd1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (555286..559051)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene palmitoyltransferase Akr1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tryptophan-tRNA ligase Wrs1 Neighboring gene ncRNA Neighboring gene exosome subunit Rrp4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation. Kobayashi A, et al. Biochem Biophys Res Commun, 2013 Jul 19. PMID 23770370
    2. Role of the RNA-binding protein Nrd1 in stress granule formation and its implication in the stress response in fission yeast. Satoh R, et al. PLoS One, 2012. PMID 22276125, Free PMC Article
    3. Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast. Oowatari Y, et al. Curr Genet, 2011 Jun. PMID 21409593
    4. Isolation of a mammalian homologue of a fission yeast differentiation regulator. Yamamoto H, et al. Mol Cell Biol, 1999 May. PMID 10207106, Free PMC Article
    5. An RNA binding protein negatively controlling differentiation in fission yeast. Tsukahara K, et al. Mol Cell Biol, 1998 Aug. PMID 9671458, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of the second RRM domain of Nrd1 was determined and the RNA binding site on the second RRM domain was mapped by NMR.
      Title: Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation.
    2. Msa2 may regulate the translation of Ste11, be a component of stress granules that form in response to glucose starvation, and regulate the sexual differentiation of S. pombe.
      Title: Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast.
    3. Pmk1 mitogen-activated protein kinase (MAPK) directly phosphorylates Nrd1, thereby negatively regulating the binding activity of Nrd1 to Cdc4 mRNA.
      Title: Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    NOT is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding protein Nrd1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      555286..559051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018382.3 → NP_592982.1  RNA-binding protein Nrd1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592982.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09702
      Conserved Domains (6) summary
      COG0724
      Location:86 → 344
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12520
      Location:114 → 187
      RRM1_MRN1; RNA recognition motif 1 of RNA-binding protein MRN1 and similar proteins
      cd12521
      Location:322 → 395
      RRM3_MRN1; RNA recognition motif 3 of RNA-binding protein MRN1 and similar proteins
      cd12522
      Location:411 → 489
      RRM4_MRN1; RNA recognition motif 4 of RNA-binding protein MRN1 and similar proteins
      cd12523
      Location:203 → 280
      RRM2_MRN1; RNA recognition motif 2 of RNA-binding protein MRN1 and similar proteins
      pfam10378
      Location:37 → 66
      RRM; Putative RRM domain
    Nucleotide Protein
    Heading Accession and Version

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