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    cwg2 geranylgeranyltransferase type 1 beta subunit Cwg2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541514, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cwg2
    Official Full Name
    geranylgeranyltransferase type 1 beta subunit Cwg2
    Primary source
    PomBase:SPAC2E1P5.04c
    Locus tag
    SPOM_SPAC2E1P5.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    orb7
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    Genomic context

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    See cwg2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3327940..3329165, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rab GTPase binding protein upregulated in meiosis II Neighboring gene DNAJ domain-containing protein Erj5 Neighboring gene U3 snoRNP-associated protein Rrp9 Neighboring gene ncRNA Neighboring gene aspartic protease Sxa1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe. Arellano M, et al. Mol Microbiol, 1998 Sep. PMID 9781874
    2. Rho 1 GTPase activates the (1-3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis. Arellano M, et al. EMBO J, 1996 Sep 2. PMID 8887550, Free PMC Article
    3. The Schizosaccharomyces pombe cwg2+ gene codes for the beta subunit of a geranylgeranyltransferase type I required for beta-glucan synthesis. Díaz M, et al. EMBO J, 1993 Dec 15. PMID 8262067, Free PMC Article
    4. Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast. Doi A, et al. Genes Cells, 2015 Apr. PMID 25651781
    5. High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library. Varberg JM, et al. G3 (Bethesda), 2020 Dec 3. PMID 33109728, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to CAAX-protein geranylgeranyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to CAAX-protein geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CAAX-protein geranylgeranyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAAX-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAAX-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    geranylgeranyltransferase type 1 beta subunit Cwg2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3327940..3329165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019566.2 → NP_594142.1  geranylgeranyltransferase type 1 beta subunit Cwg2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594142.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P32434
      Conserved Domains (2) summary
      COG5029
      Location:2 → 351
      CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
      cd02895
      Location:5 → 323
      GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
    Nucleotide Protein
    Heading Accession and Version

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