aps1 diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: aps1
Official Full Name: diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1
Primary source: PomBase:SPAC13G6.14
Locus tag: SPOM_SPAC13G6.14
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: SPAC24B11.03; stw1
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Genomic context

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See aps1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (200038..201517)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The specific Aps1 residues involved in binding of diadenosine oligophosphates and diphosphoinositol polyphosphates substrates were determined.
Title: Kinetic, dynamic, ligand binding properties, and structural models of a dual-substrate specific nudix hydrolase from Schizosaccharomyces pombe.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables bis(5'-adenosyl)-hexaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-hexaphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables bis(5'-adenosyl)-hexaphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables bis(5'-adenosyl)-pentaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-pentaphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables bis(5'-adenosyl)-triphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables bis(5'-nucleosyl)-tetraphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables diphosphoinositol-polyphosphate diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphoinositol-polyphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopolyphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol phosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diadenosine hexaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine hexaphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diadenosine pentaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine pentaphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diadenosine polyphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diphosphoinositol polyphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	HDA more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

200038..201517

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018241.3 → NP_592840.1 diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase Aps1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_592840.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q09790

Conserved Domains (1) summary

cd04666
Location:43 → 198

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...