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    STR3 cystathionine beta-lyase STR3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STR3
    Official Full Name
    cystathionine beta-lyase STR3
    Primary source
    SGD:S000003152
    Locus tag
    YGL184C
    See related
    AllianceGenome:SGD:S000003152; FungiDB:YGL184C; VEuPathDB:YGL184C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cysteine-S-conjugate beta-lyase activity. Involved in methionine biosynthetic process and transsulfuration. Located in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STR3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (154615..156012, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Tpn1p Neighboring gene putative hydroxyacid dehydrogenase Neighboring gene Mnd1p Neighboring gene Gts1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of peroxisomal membrane proteins of Saccharomyces cerevisiae by mass spectrometry. Schäfer H, et al. Electrophoresis, 2001 Aug. PMID 11565790
    2. Engineering Saccharomyces cerevisiae to release 3-Mercaptohexan-1-ol during fermentation through overexpression of an S. cerevisiae Gene, STR3, for improvement of wine aroma. Holt S, et al. Appl Environ Microbiol, 2011 Jun. PMID 21478306, Free PMC Article
    3. Generation of 2-Furfurylthiol by Carbon-Sulfur Lyase from the Baijiu Yeast Saccharomyces cerevisiae G20. Zha M, et al. J Agric Food Chem, 2018 Mar 7. PMID 29436228
    4. STR3 and CYS3 Contribute to 2-Furfurylthiol Biosynthesis in Chinese Sesame-Flavored Baijiu Yeast. Zha M, et al. J Agric Food Chem, 2017 Jul 12. PMID 28603986
    5. Acrolein-stressed threshold adaptation alters the molecular and metabolic bases of an engineered Saccharomyces cerevisiae to improve glutathione production. Zhou W, et al. Sci Rep, 2018 Mar 14. PMID 29540749, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carbon-sulfur lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-S-conjugate beta-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-S-conjugate beta-lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cysteine-S-conjugate beta-lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' L-methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transsulfuration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transsulfuration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cystathionine beta-lyase STR3
    NP_011331.3
    • Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      154615..156012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181049.3 → NP_011331.3  TPA: cystathionine beta-lyase STR3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011331.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTX0, P53101
      UniProtKB/TrEMBL
      A6ZU04, C7GX10, C8Z868, E3VL26, N1P4L6
      Conserved Domains (1) summary
      TIGR01329
      Location:6 → 409
      cysta_beta_ly_E; cystathionine beta-lyase, eukaryotic
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53101.1

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