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    brr2 U5 snRNP complex subunit Brr2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543676, updated on 18-Sep-2024

    Summary

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    Official Symbol
    brr2
    Official Full Name
    U5 snRNP complex subunit Brr2
    Primary source
    PomBase:SPAC9.03c
    Locus tag
    SPOM_SPAC9.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    spp41
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    Genomic context

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    See brr2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1458445..1465279, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene polyamine N-acetyltransferase Neighboring gene glucose-6-phosphate 1-dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene retrotransposable element/transposon Tf2-type

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p. Schmidt H, et al. Genetics, 1999 Nov. PMID 10545451, Free PMC Article
    2. Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe. Bottner CA, et al. Curr Genet, 2005 Sep. PMID 16133344
    3. The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast. Aronica L, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26682798, Free PMC Article
    4. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Lee NN, et al. Cell, 2013 Nov 21. PMID 24210919, Free PMC Article
    5. Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay. Grenier St-Sauveur V, et al. Mol Cell Biol, 2013 Dec. PMID 24081329, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prp1 and Brr2 are complexed in vivo with spliceosomal particles containing the five snRNAs U1, U2, U5, and base-paired U4/U6
      Title: Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in spliceosomal conformational changes to generate catalytic conformation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U5 snRNP complex subunit Brr2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1458445..1465279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018778.3 → NP_593346.1  U5 snRNP complex subunit Brr2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593346.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UT24
      Conserved Domains (6) summary
      smart00490
      Location:811 → 898
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:1361 → 1560
      DEXDc; DEAD-like helicases superfamily
      smart00611
      Location:1845 → 2163
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:483 → 1283
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      pfam00270
      Location:521 → 695
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:1019 → 1323
      Sec63; Sec63 Brl domain
    Nucleotide Protein
    Heading Accession and Version

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