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    TOD6 Tod6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOD6
    Official Full Name
    Tod6p
    Primary source
    SGD:S000000150
    Locus tag
    YBL054W
    See related
    AllianceGenome:SGD:S000000150; FungiDB:YBL054W; VEuPathDB:YBL054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PBF1
    Summary
    Enables sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of Rpd3L-Expanded complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOD6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (117589..119166)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene type 2C protein phosphatase PTC3 Neighboring gene 3'-5'-exodeoxyribonuclease Neighboring gene histone acetyltransferase Neighboring gene Pin4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of nucleosome positioning in the evolution of gene regulation. Tsankov AM, et al. PLoS Biol, 2010 Jul 6. PMID 20625544, Free PMC Article
    2. Decoupling Yeast Cell Division and Stress Defense Implicates mRNA Repression in Translational Reallocation during Stress. Ho YH, et al. Curr Biol, 2018 Aug 20. PMID 30078561, Free PMC Article
    3. Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6. Lippman SI, et al. Proc Natl Acad Sci U S A, 2009 Nov 24. PMID 19901341, Free PMC Article
    4. A dynamic model of proteome changes reveals new roles for transcript alteration in yeast. Lee MV, et al. Mol Syst Biol, 2011 Jul 19. PMID 21772262, Free PMC Article
    5. Multiplex navigation of global regulatory networks (MINR) in yeast for improved ethanol tolerance and production. Liu R, et al. Metab Eng, 2019 Jan. PMID 30030154

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results establish Dot6/Tod6 as a direct link between nutrient availability, Ribi gene regulation, and growth control through protein kinase A and TORC1.
      Title: Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tod6p
    NP_009499.1
    • PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      117589..119166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178294.1 → NP_009499.1  TPA: Tod6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009499.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPU6, P34219
      UniProtKB/TrEMBL
      N1P8Y9
      Conserved Domains (1) summary
      cd00167
      Location:77 → 120
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34219.1

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