ACF2 endo-1,3(4)-beta-glucanase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ACF2
Official Full Name: endo-1,3(4)-beta-glucanase
Primary source: SGD:S000004134
Locus tag: YLR144C
See related: AllianceGenome:SGD:S000004134; FungiDB:YLR144C; VEuPathDB:YLR144C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ENG2; PCA1
Summary: Enables glucan endo-1,3-beta-D-glucosidase activity. Involved in actin cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

four conserved Asp and Glu residues (D518, D588, E609, and E613) are necessary for enzymatic activity.
Title: Characterization of the endo-beta-1,3-glucanase activity of S. cerevisiae Eng2 and other members of the GH81 family.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables endo-1,3(4)-beta-glucanase activity	IEA Inferred from Electronic Annotation more info
enables glucan endo-1,3-beta-D-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucan endo-1,3-beta-D-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucan endo-1,3-beta-D-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables glucan endo-1,3-beta-D-glucosidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in polysaccharide catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NP_013245.1

Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress

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