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    MTH1 Mth1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851870, updated on 9-Dec-2024

    Summary

    Official Symbol
    MTH1
    Official Full Name
    Mth1p
    Primary source
    SGD:S000002685
    Locus tag
    YDR277C
    See related
    AllianceGenome:SGD:S000002685; FungiDB:YDR277C; VEuPathDB:YDR277C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BPC1; DGT1; HTR1
    Summary
    Involved in D-glucose transmembrane transport and signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MTH1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1014401..1015702, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene triglyceride-associated lipolysis regulator TLD1 Neighboring gene Pmp3p Neighboring gene tRNA-Glu Neighboring gene Rnh202p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    Mth1p
    NP_010563.3
    • Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1014401..1015702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180585.3NP_010563.3  TPA: Mth1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010563.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSQ8, P35198
      UniProtKB/TrEMBL
      A6ZYM7, B3LG16, B5VGF7, C7GS95, C8Z5J0, G2WB17, N1P8J2
      Conserved Domains (1) summary
      pfam17235
      Location:121333
      STD1; STD1/MTH1