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    AGP1 amino acid transporter AGP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AGP1
    Official Full Name
    amino acid transporter AGP1
    Primary source
    SGD:S000000530
    Locus tag
    YCL025C
    See related
    AllianceGenome:SGD:S000000530; FungiDB:YCL025C; VEuPathDB:YCL025C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    WAP1; YCC5
    Summary
    Enables L-proline transmembrane transporter activity. Involved in serine import across plasma membrane. Located in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A14 (solute carrier family 7 member 14). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AGP1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (76018..77919, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative nitroreductase Neighboring gene type II nitroreductase Neighboring gene serine/threonine protein kinase Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine. Schreve JL, et al. J Bacteriol, 1998 May. PMID 9573211, Free PMC Article
    2. [Effects of transporter Agp1p ubiquitination on nitrogen utilization in Saccharomyces cerevisiae]. Li Y, et al. Wei Sheng Wu Xue Bao, 2015 May 4. PMID 26259481
    3. Mapping genetic variants underlying differences in the central nitrogen metabolism in fermenter yeasts. Jara M, et al. PLoS One, 2014. PMID 24466135, Free PMC Article
    4. L-Phenylalanine Transport in Saccharomyces cerevisiae: Participation of GAP1, BAP2, and AGP1. Sáenz DA, et al. J Amino Acids, 2014. PMID 24701347, Free PMC Article
    5. Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast. Andréasson C, et al. Yeast, 2004 Feb. PMID 14968425

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of the broad-specificity amino acid permease Agp1 mediated by the ubiquitin ligase Rsp5 and the arrestin-like protein Bul1 in yeast.
      Title: Downregulation of the broad-specificity amino acid permease Agp1 mediated by the ubiquitin ligase Rsp5 and the arrestin-like protein Bul1 in yeast.
    2. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
      Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
    3. Ubiquitination sites of Agp1 significantly affect the nitrogen utilization.
      Title: [Effects of transporter Agp1p ubiquitination on nitrogen utilization in Saccharomyces cerevisiae].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylalanine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in serine import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in serine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    amino acid transporter AGP1
    NP_009905.3
    • Broad-specificity, low-affinity amino acid permease; minor serine permease with major contributions from paralog Gnp1p; involved in uptake of asparagine, glutamine, and other amino acids; expression induced by amino acids and regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      76018..77919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178671.1 → NP_009905.3  TPA: amino acid transporter AGP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009905.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQZ1, P25376
      UniProtKB/TrEMBL
      B3LU57, C7GSY2, N1P7S5
      Conserved Domains (1) summary
      TIGR00913
      Location:117 → 597
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25376.3

    Gene LinkOut

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