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    MND1 Mnd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MND1
    Official Full Name
    Mnd1p
    Primary source
    SGD:S000003151
    Locus tag
    YGL183C
    See related
    AllianceGenome:SGD:S000003151; FungiDB:YGL183C; VEuPathDB:YGL183C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables double-stranded DNA binding activity. Involved in reciprocal meiotic recombination. Located in condensed nuclear chromosome. Orthologous to human MND1 (meiotic nuclear divisions 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MND1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    2
    Sequence:
    Chromosome: VII; NC_001139.9 (156543..157285, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative hydroxyacid dehydrogenase Neighboring gene cystathionine beta-lyase STR3 Neighboring gene Gts1p Neighboring gene serine/threonine protein kinase ATG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mnd1p: an evolutionarily conserved protein required for meiotic recombination. Gerton JL, et al. Proc Natl Acad Sci U S A, 2002 May 14. PMID 12011448, Free PMC Article
    2. Dynamic interactions of the homologous pairing 2 (Hop2)-meiotic nuclear divisions 1 (Mnd1) protein complex with meiotic presynaptic filaments in budding yeast. Crickard JB, et al. J Biol Chem, 2019 Jan 11. PMID 30420424, Free PMC Article
    3. Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation. Chen YK, et al. Proc Natl Acad Sci U S A, 2004 Jul 20. PMID 15249670, Free PMC Article
    4. Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination. Kang HA, et al. Nucleic Acids Res, 2015 Apr 20. PMID 25740648, Free PMC Article
    5. The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair. Tsubouchi H, et al. Mol Cell Biol, 2002 May. PMID 11940665, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hop2-Mnd1 bound rapidlyto Dmc1-ssDNA filaments with high affinity and remained bound for approximately 1.3 min before dissociating.
      Title: Dynamic interactions of the homologous pairing 2 (Hop2)-meiotic nuclear divisions 1 (Mnd1) protein complex with meiotic presynaptic filaments in budding yeast.
    2. findings allow us to propose a model explaining how Hop2-Mnd1 juxtaposes Dmc1-bound ssDNA with distorted recipient double-stranded DNA and thus facilitates strand invasion
      Title: Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination.
    3. bipartite mechanism of Hop2-Mnd1 in homologous DNA pairing: stabilization of the Rad51 presynaptic filament and duplex DNA capture to enhance synaptic complex formation
      Title: Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.
    4. Mnd1 facilitates Dmc1-dependent interhomolog crossover formation in meiosis.
      Title: Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables recombinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic joint molecule formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic strand invasion involved in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA recombinase auxiliary factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mnd1p
    NP_011332.2
    • Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      156543..157285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181048.1 → NP_011332.2  TPA: Mnd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011332.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTX1, P53102
      UniProtKB/TrEMBL
      A6ZU05, C8Z869, G2WDS4
      Conserved Domains (1) summary
      COG5124
      Location:8 → 219
      COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53102.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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