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    VAC7 Vac7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VAC7
    Official Full Name
    Vac7p
    Primary source
    SGD:S000004999
    Locus tag
    YNL054W
    See related
    AllianceGenome:SGD:S000004999; FungiDB:YNL054W; VEuPathDB:YNL054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme activator activity. Involved in positive regulation of phosphatidylinositol biosynthetic process and protein localization to vacuolar membrane. Located in fungal-type vacuole membrane. Part of PAS complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VAC7 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (526086..529583)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tyrosine/serine/threonine protein phosphatase MSG5 Neighboring gene cytochrome c oxidase subunit Va

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. Gary JD, et al. J Cell Biol, 1998 Oct 5. PMID 9763421, Free PMC Article
    2. Characterization of new vacuolar segregation mutants, isolated by screening for loss of proteinase B self-activation. Gomes de Mesquita DS, et al. Eur J Cell Biol, 1996 Nov. PMID 8929562
    3. PI(3,5)P2 asymmetry during mitosis is essential for asymmetric vacuolar inheritance. Huda M, et al. J Cell Biol, 2025 Jan 6. PMID 39514241,
    4. Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Bonangelino CJ, et al. Mol Cell Biol, 1997 Dec. PMID 9372916, Free PMC Article
    5. Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Gary JD, et al. Mol Biol Cell, 2002 Apr. PMID 11950935, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
      Title: TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to vacuolar membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole inheritance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PAS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PAS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PAS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vac7p
    NP_014344.3
    • Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      526086..529583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182893.3 → NP_014344.3  TPA: Vac7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014344.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1C5, P53950
      UniProtKB/TrEMBL
      G2WM49, N1NZI9
      Conserved Domains (1) summary
      pfam12751
      Location:923 → 1001
      Vac7; Vacuolar segregation subunit 7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53950.1

    Gene LinkOut

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