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    BUD13 Bud13p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BUD13
    Official Full Name
    Bud13p
    Primary source
    SGD:S000003142
    Locus tag
    YGL174W
    See related
    AllianceGenome:SGD:S000003142; FungiDB:YGL174W; VEuPathDB:YGL174W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CWC26
    Summary
    Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of RES complex. Orthologous to human BUD13 (BUD13 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BUD13 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (174545..175345)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ssDNA endodeoxyribonuclease SAE2 Neighboring gene chromatin-binding exonuclease XRN1 Neighboring gene FG-nucleoporin NUP49

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex. Trowitzsch S, et al. J Biol Chem, 2008 Nov 21. PMID 18809678
    2. Structure of the yeast Pml1 splicing factor and its integration into the RES complex. Brooks MA, et al. Nucleic Acids Res, 2009 Jan. PMID 19033360, Free PMC Article
    3. QTL analysis of natural Saccharomyces cerevisiae isolates reveals unique alleles involved in lignocellulosic inhibitor tolerance. de Witt RN, et al. FEMS Yeast Res, 2019 Aug 1. PMID 31276593
    4. A novel protein-protein interaction in the RES (REtention and Splicing) complex. Tripsianes K, et al. J Biol Chem, 2014 Oct 10. PMID 25160624, Free PMC Article
    5. Retention and splicing complex (RES) - the importance of cooperativity. Wysoczanski P, et al. RNA Biol, 2016. PMID 26479714, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RES is a 71 kDa heterotrimer composed of the 3 proteins Pml1p, Bud13p and Snu17p. We solved the 3-dimensional structure of the core of the RES complex as well as the 2 dimers, Snu17p-Bud13p and Snu17p-Pml1p
      Title: Retention and splicing complex (RES) - the importance of cooperativity.
    2. The RES proteins Pml1 and Bud13 were shown to contact the intron downstream of the branch-site. A comparison of the B(act) crosslinking pattern versus that of B* and C complexes revealed that U2 and RES protein interactions with the intron are dynamic.
      Title: Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes.
    3. An extended binding interface has been described between the Snu17p RNA recognition motif and Bud13p of the retention and splicing complex.
      Title: A novel protein-protein interaction in the RES (REtention and Splicing) complex.
    4. Snu17p RRM binds multiple ligand proteins and acts as a platform that displays functional modules of the ligands, including forkhead-associated domain of Pml1p and conserved polylysine motif of Bud13p
      Title: An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RES complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bud13p
    NP_011341.3
    • Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      174545..175345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181039.3 → NP_011341.3  TPA: Bud13p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011341.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTX8, P46947
      UniProtKB/TrEMBL
      A6ZU12, B3LHM6, C7GPN3, C8Z877, G2WDT1, N1P2W3
      Conserved Domains (1) summary
      pfam09736
      Location:120 → 249
      Bud13; Pre-mRNA-splicing factor of RES complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46947.1

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