U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tip1 CLIP170 family protein Tip1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543044, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tip1
    Official Full Name
    CLIP170 family protein Tip1
    Primary source
    PomBase:SPAC3C7.12
    Locus tag
    SPOM_SPAC3C7.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    noc1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tip1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2089289..2091311)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene peroxin 13 Neighboring gene ncRNA Neighboring gene calnexin Cnx1 Neighboring gene glucose-6-phosphate 1-dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NAD(P)H dehydrogenase (quinone)

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast. Brunner D, et al. Cell, 2000 Sep 1. PMID 11007487
    2. The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules. Busch KE, et al. Curr Biol, 2004 Apr 6. PMID 15062095
    3. Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast. Daga RR, et al. J Cell Sci, 2008 Jun 15. PMID 18495844
    4. Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP mutants. Höög JL, et al. PLoS One, 2013. PMID 23613905, Free PMC Article
    5. Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress. Wang X, et al. Nat Commun, 2022 Sep 22. PMID 36138017, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S. pombe Tip1/CLIP170 is directly or indirectly required for correct chromosome poleward movement independently of Mal3/EB1.
      Title: Tip1/CLIP-170 protein is required for correct chromosome poleward movement in fission yeast.
    2. Myo52 facilitates microtubule catastrophe by enhancing Tip1 removal from the plus end of growing microtubules at the cell tips.
      Title: Myosin V spatially regulates microtubule dynamics and promotes the ubiquitin-dependent degradation of the fission yeast CLIP-170 homologue, Tip1.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cytoplasmic microtubule plus-end IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cytoplasmic microtubule EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    NOT is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle astral microtubule end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in post-anaphase array microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    CLIP170 family protein Tip1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2089289..2091311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019044.3 → NP_593613.1  CLIP170 family protein Tip1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593613.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P79065
      Conserved Domains (3) summary
      smart01052
      Location:4 → 74
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      pfam15272
      Location:140 → 238
      BBP1_C; Spindle pole body component BBP1, C-terminal
      cl09139
      Location:101 → 187
      FliE; Flagellar hook-basal body complex protein FliE
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials