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    LST4 Lst4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LST4
    Official Full Name
    Lst4p
    Primary source
    SGD:S000001659
    Locus tag
    YKL176C
    See related
    AllianceGenome:SGD:S000001659; FungiDB:YKL176C; VEuPathDB:YKL176C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to GTPase activator activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Located in vacuolar membrane. Part of FNIP-folliculin RagC/D GAP. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LST4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (115500..117986, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Coy1p Neighboring gene Ste3p Neighboring gene Zn(2+) transporter ZRT3 Neighboring gene Tpo5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments. Hong J, et al. PLoS Genet, 2014 Jan. PMID 24415948, Free PMC Article
    2. Yeast genes involved in regulating cysteine uptake affect production of hydrogen sulfide from cysteine during fermentation. Huang CW, et al. FEMS Yeast Res, 2017 Aug 1. PMID 28810701
    3. Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2. Péli-Gulli MP, et al. Cell Rep, 2015 Oct 6. PMID 26387955
    4. Different ubiquitin signals act at the Golgi and plasma membrane to direct GAP1 trafficking. Risinger AL, et al. Mol Biol Cell, 2008 Jul. PMID 18434603, Free PMC Article
    5. Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals. Péli-Gulli MP, et al. Cell Rep, 2017 Jul 11. PMID 28700931

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Amino acids stimulate TORC1 through Lst4-Lst7, a GTPase-activating protein complex for the Rag family GTPase Gtr2.
      Title: Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lst4p
    NP_012745.1
    • Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      115500..117986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179742.1 → NP_012745.1  TPA: Lst4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012745.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX24, P34239
      UniProtKB/TrEMBL
      B3LQS9, C8ZBZ9, N1NZM7
      Conserved Domains (1) summary
      pfam18639
      Location:118 → 288
      Longin_2; Yeast longin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34239.1

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