myo1 myosin I myo1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: myo1
Official Full Name: myosin I myo1
Primary source: PomBase:SPBC146.13c
Locus tag: SPOM_SPBC146.13C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See myo1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 2

Sequence:: Chromosome: II; NC_003423.3 (1023963..1027973, complement)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, the authors define a novel regulatory mechanism by which the motor activity and function of the fission yeast type one myosin, Myo1, is modulated by TORC2-signalling-dependent phosphorylation via Gad8.
Title: TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium.
Yeast strains expressing mutant Myo1 exhibited defects in growth and endocytosis similar to those observed in the myo1 deletion strain.
Title: Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast.
proteins encoded by the Myo1-associated mRNAs immunoprecipitated each other's transcripts, but not myosin mRNAs
Title: Genome-wide mapping of myosin protein-RNA networks suggests the existence of specialized protein production sites.
Phosphorylation of the Myo1 TEDS site by Pak1 and Nak1 plays a crucial role in regulating Myo1 localisation and cellular function.
Title: Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.
myo1p, is required for proper organization of distinct sterol-rich membrane domains.
Title: Role of fission yeast myosin I in organization of sterol-rich membrane domains.
These results suggest a close relationship between Cam2 and Myo1. In addition, both F-actin and Myo1 localized with Cam2 in the leading edge region.
Title: Localization of type I myosin and F-actin to the leading edge region of the forespore membrane in Schizosaccharomyces pombe.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G38095 (e-PCR)
- UniSTS:68042

Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IC Inferred by Curator more info
enables Arp2/3 complex binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	EXP Inferred from Experiment more info	PubMed
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cortical patch assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin cortical patch assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cortical patch localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in dynein-driven meiotic oscillatory nuclear movement	EXP Inferred from Experiment more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cortical patch	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell cortex of cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell tip	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endocytic patch	EXP Inferred from Experiment more info	PubMed
is_active_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in medial cortex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin I complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in plasma membrane	EXP Inferred from Experiment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in prospore membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin I myo1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

1023963..1027973 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001021309.3 → NP_595402.1 myosin I myo1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_595402.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q9Y7Z8

Conserved Domains (4) summary

cd11858
Location:1111 → 1162

SH3_Myosin-I_fungi; Src homology 3 domain of Type I fungal Myosins

smart00242
Location:38 → 720

MYSc; Myosin. Large ATPases

cd01378
Location:54 → 707

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:765 → 944

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding