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    rnc1 RNA-binding protein Rnc1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539434, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rnc1
    Official Full Name
    RNA-binding protein Rnc1
    Primary source
    PomBase:SPCC757.09c
    Locus tag
    SPOM_SPCC757.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rnc1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (64099..66962, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene exosome subunit Rrp45 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transporter Neighboring gene V-ATPase assembly protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct modes of stress granule assembly mediated by the KH-type RNA-binding protein Rnc1. Satoh R, et al. Genes Cells, 2018 Sep. PMID 30014536
    2. In vitro assay of the interaction between Rnc1 protein and Pmp1 mRNA by affinity capillary electrophoresis with a carboxylated capillary. Taga A, et al. J Pharm Biomed Anal, 2010 Dec 15. PMID 20692117
    3. Spatial regulation of the KH domain RNA-binding protein Rnc1 mediated by a Crm1-independent nuclear export system in Schizosaccharomyces pombe. Satoh R, et al. Mol Microbiol, 2017 May. PMID 28142187
    4. Feedback regulation of MAPK signalling by an RNA-binding protein. Sugiura R, et al. Nature, 2003 Aug 21. PMID 12931193
    5. RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway. Prieto-Ruiz F, et al. mBio, 2020 Jan 7. PMID 31911490, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rnc1 regulates stress granule assembly, dependently or independently of its RNA-binding activity.
      Title: Distinct modes of stress granule assembly mediated by the KH-type RNA-binding protein Rnc1.
    2. The functional Rae1-dependent mRNA export system may influence the cytoplasmic localization and function of Rnc1.
      Title: Spatial regulation of the KH domain RNA-binding protein Rnc1 mediated by a Crm1-independent nuclear export system in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in 3'-UTR-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-UTR-mediated mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell integrity MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein Rnc1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      64099..66962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022679.3 → NP_587684.1  RNA-binding protein Rnc1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587684.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74919
      Conserved Domains (2) summary
      cd00105
      Location:322 → 385
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:181 → 243
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    Nucleotide Protein
    Heading Accession and Version

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