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    YSY6 Ysy6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YSY6
    Official Full Name
    Ysy6p
    Primary source
    SGD:S000002158
    Locus tag
    YBR162W-A
    See related
    AllianceGenome:SGD:S000002158; FungiDB:YBR162W-A; VEuPathDB:YBR162W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein secretion. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YSY6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (565231..565428)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 Neighboring gene Tos1p Neighboring gene Exo5p Neighboring gene Arf family GTPase ARL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast gene which suppresses the defect in protein export of a secY mutant of E. coli. Sakaguchi M, et al. J Biochem, 1991 Jun. PMID 1938999
    2. Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. Schröder K, et al. EMBO J, 1999 Sep 1. PMID 10469658, Free PMC Article
    3. Identification and characterization of protein interactions with the major Niemann-Pick type C disease protein in yeast reveals pathways of therapeutic potential. Hammond N, et al. Genetics, 2023 Aug 31. PMID 37440478, Free PMC Article
    4. The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Schuldiner M, et al. Cell, 2008 Aug 22. PMID 18724936, Free PMC Article
    5. ATP synthase interactome analysis identifies a new subunit l as a modulator of permeability transition pore in yeast. Panja C, et al. Sci Rep, 2023 Mar 7. PMID 36882574, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ysy6p
    NP_009721.1
    • hypothetical protein; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      565231..565428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180059.1 → NP_009721.1  TPA: Ysy6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQF8, P38374
      UniProtKB/TrEMBL
      A6ZLA5, B3LMZ6, C7GUH7, D3UEQ7, G2W9G5, N1P9I6
      Conserved Domains (1) summary
      pfam06624
      Location:3 → 61
      RAMP4; Ribosome associated membrane protein RAMP4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38374.1

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