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    pgt1 plasma membrane glutathione transmembrane transporter Pgt1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542082, updated on 14-Nov-2024

    Summary

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    Official Symbol
    pgt1
    Official Full Name
    plasma membrane glutathione transmembrane transporter Pgt1
    Primary source
    PomBase:SPAC29B12.10c
    Locus tag
    SPOM_SPAC29B12.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    opt1
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    Genomic context

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    See pgt1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5431575..5434787, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene silencing factor Clr5 Neighboring gene ncRNA Neighboring gene WW domain-binding protein Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pgt1, a glutathione transporter from the fission yeast Schizosaccharomyces pombe. Thakur A, et al. FEMS Yeast Res, 2008 Sep. PMID 18662319
    2. SpOPT1, a member of the oligopeptide family (OPT) of the fission yeast Schizosaccharomyces pombe, is involved in the transport of glutathione through the outer membrane of the cell. Dworeck T, et al. Yeast, 2009 Jan. PMID 19180638
    3. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    4. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPAC29B12.10c is named SpOPT1 and it localizes within the plasma membrane and transports the glutathione.
      Title: SpOPT1, a member of the oligopeptide family (OPT) of the fission yeast Schizosaccharomyces pombe, is involved in the transport of glutathione through the outer membrane of the cell.
    2. Identified as a gene encoding the S. pombe glutathione transporter (Pgt1) by a genetic strategy that exploited the requirement of the cys1aDelta strain of S. pombe for either cysteine or glutathione, for growth.
      Title: Pgt1, a glutathione transporter from the fission yeast Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables glutathione transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables glutathione transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oligopeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione import across plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in glutathione import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasma membrane glutathione transmembrane transporter Pgt1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5431575..5434787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020418.3 → NP_594987.1  plasma membrane glutathione transmembrane transporter Pgt1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594987.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14031
      Conserved Domains (1) summary
      TIGR00728
      Location:135 → 813
      OPT_sfam; oligopeptide transporter, OPT superfamily
    Nucleotide Protein
    Heading Accession and Version

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