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    met8 siroheme synthase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543624, updated on 18-Sep-2024

    Summary

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    Official Symbol
    met8
    Official Full Name
    siroheme synthase
    Primary source
    PomBase:SPAC4D7.06c
    Locus tag
    SPOM_SPAC4D7.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See met8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (5360356..5361574, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene cis-prenyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translation initiation factor eIF3i Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Csi2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. Fontebasso Y, et al. DNA Repair (Amst), 2013 Dec. PMID 24192486, Free PMC Article
    2. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article
    3. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
    4. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
    5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables precorrin-2 dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sirohydrochlorin ferrochelatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in siroheme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    siroheme synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5360356..5361574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020390.3 → NP_594959.1  siroheme synthase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594959.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14172
      Conserved Domains (4) summary
      COG1648
      Location:13 → 225
      CysG2; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]
      pfam13241
      Location:16 → 128
      NAD_binding_7; Putative NAD(P)-binding
      pfam14823
      Location:164 → 224
      Sirohm_synth_C; Sirohaem biosynthesis protein C-terminal
      pfam14824
      Location:135 → 158
      Sirohm_synth_M; Sirohaem biosynthesis protein central
    Nucleotide Protein
    Heading Accession and Version

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