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    prp10 U2 snRNP-associated protein SF3B1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541619, updated on 18-Sep-2024

    Summary

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    Official Symbol
    prp10
    Official Full Name
    U2 snRNP-associated protein SF3B1
    Primary source
    PomBase:SPAC27F1.09c
    Locus tag
    SPOM_SPAC27F1.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    sap155; SF3b155
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    Genomic context

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    See prp10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4333135..4336804, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase Ost1 Neighboring gene ncRNA Neighboring gene Nramp family Mn(2+) transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PWWP domain-containing protein Neighboring gene DNA replication factor C complex subunit Rfc2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA. Bergot T, et al. Cancers (Basel), 2020 Mar 11. PMID 32168916, Free PMC Article
    2. The fission yeast prp10(+) gene involved in pre-mRNA splicing encodes a homologue of highly conserved splicing factor, SAP155. Habara Y, et al. Nucleic Acids Res, 1998 Dec 15. PMID 9837997, Free PMC Article
    3. Mutation in the prp12+ gene encoding a homolog of SAP130/SF3b130 causes differential inhibition of pre-mRNA splicing and arrest of cell-cycle progression in Schizosaccharomyces pombe. Habara Y, et al. RNA, 2001 May. PMID 11350031, Free PMC Article
    4. The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro. Banerjee H, et al. RNA, 2004 Feb. PMID 14730023, Free PMC Article
    5. Mutations in the large subunit of U2AF disrupt pre-mRNA splicing, cell cycle progression and nuclear structure. Beales M, et al. Yeast, 2000 Aug. PMID 10923022

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mRNA cis splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA-mediated pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U2 snRNP-associated protein SF3B1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4333135..4336804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019967.3 → NP_594538.2  U2 snRNP-associated protein SF3B1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594538.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10178, Q9USE7
      Conserved Domains (4) summary
      COG5181
      Location:34 → 1166
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      pfam11865
      Location:770 → 818
      DUF3385; Domain of unknown function (DUF3385)
      pfam13513
      Location:849 → 904
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:712 → 736
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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