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    hcn1 anaphase-promoting complex TPR lobe accessory factor subunit Hcn1/Apc12 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542045, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hcn1
    Official Full Name
    anaphase-promoting complex TPR lobe accessory factor subunit Hcn1/Apc12
    Primary source
    PomBase:SPAC23C11.12
    Locus tag
    SPOM_SPAC23C11.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    apc12
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    Genomic context

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    See hcn1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2154627..2155037)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Cka1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene xanthine phosphoribosyltransferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27. Zhang Z, et al. EMBO J, 2010 Nov 3. PMID 20924356, Free PMC Article
    2. Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast. Yamada H, et al. J Cell Sci, 1997 Aug. PMID 9264466
    3. Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function. Yoon HJ, et al. J Biol Chem, 2006 Oct 27. PMID 16950791
    4. Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Ohi MD, et al. Mol Cell, 2007 Dec 14. PMID 18082611, Free PMC Article
    5. The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C). Sczaniecka M, et al. J Biol Chem, 2008 Aug 22. PMID 18556659, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of hcn1 and its phosphorylation in anaphase-promoting complex function is elucidated.
      Title: Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex TPR lobe accessory factor subunit Hcn1/Apc12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2154627..2155037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019074.2 → NP_593643.1  anaphase-promoting complex TPR lobe accessory factor subunit Hcn1/Apc12 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593643.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13916
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 26
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26
    Nucleotide Protein
    Heading Accession and Version

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