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    ZRT3 Zn(2+) transporter ZRT3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZRT3
    Official Full Name
    Zn(2+) transporter ZRT3
    Primary source
    SGD:S000001658
    Locus tag
    YKL175W
    See related
    AllianceGenome:SGD:S000001658; FungiDB:YKL175W; VEuPathDB:YKL175W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables zinc ion transmembrane transporter activity. Involved in intracellular zinc ion homeostasis and zinc ion transport. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZRT3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (118793..120304)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ste3p Neighboring gene Lst4p Neighboring gene Tpo5p Neighboring gene U5 snRNP GTPase SNU114

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation. Yang X, et al. J Cell Biol, 2021 Aug 2. PMID 34047770, Free PMC Article
    2. Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. MacDiarmid CW, et al. EMBO J, 2000 Jun 15. PMID 10856230, Free PMC Article
    3. Proteomic and genetic analysis of the response of S. cerevisiae to soluble copper leads to improvement of the antimicrobial function of cellulosic copper nanoparticles. Rong-Mullins X, et al. Metallomics, 2017 Sep 20. PMID 28869270, Free PMC Article
    4. Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Lyons TJ, et al. Proc Natl Acad Sci U S A, 2000 Jul 5. PMID 10884426, Free PMC Article
    5. Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. Li M, et al. J Cell Biol, 2015 Nov 9. PMID 26527740, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zn(2+) transporter ZRT3
    NP_012746.1
    • Vacuolar membrane zinc transporter; transports zinc from storage in vacuole to cytoplasm when needed; transcription induced under conditions of zinc deficiency; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      118793..120304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179741.1 → NP_012746.1  TPA: Zn(2+) transporter ZRT3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX25, P34240
      UniProtKB/TrEMBL
      A6ZZF0, B3LQT0, C7GJ34, G2WHL7, N1P896
      Conserved Domains (2) summary
      COG0428
      Location:319 → 495
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
      cl00437
      Location:8 → 93
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34240.2

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