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    sen1 helicase Sen1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541556, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sen1
    Official Full Name
    helicase Sen1
    Primary source
    PomBase:SPAC6G9.10c
    Locus tag
    SPOM_SPAC6G9.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sen1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3262405..3268040, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp6 Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL24 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene synaptobrevin family receptor Neighboring gene CHS5-like protein Cfr1 Neighboring gene bouquet formation protein Bqt1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sen1(+) gene of Schizosaccharomyces pombe, a homologue of budding yeast SEN1, encodes an RNA and DNA helicase. Kim HD, et al. Biochemistry, 1999 Nov 2. PMID 10545196
    2. Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription. Rivosecchi J, et al. EMBO J, 2019 Aug 15. PMID 31294478, Free PMC Article
    3. RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes. Legros P, et al. PLoS Genet, 2014 Nov. PMID 25392932, Free PMC Article
    4. The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection. Lemay JF, et al. Genes Dev, 2016 Jul 1. PMID 27401558, Free PMC Article
    5. CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. Vanoosthuyse V, et al. PLoS Genet, 2014 Jun. PMID 24945319, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 5'-3' DNA/RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-3' RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription termination site sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in termination of RNA polymerase II transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of RNA polymerase III transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT part_of Nrd1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    helicase Sen1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3262405..3268040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019543.3 → NP_594119.1  helicase Sen1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594119.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q92355
      Conserved Domains (5) summary
      COG1112
      Location:765 → 1641
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam12726
      Location:53 → 693
      SEN1_N; SEN1 N terminal
      pfam13087
      Location:1422 → 1618
      AAA_12; AAA domain
      pfam13245
      Location:1137 → 1212
      AAA_19; Part of AAA domain
      cl21455
      Location:1350 → 1410
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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