RPT4 proteasome regulatory particle base subunit RPT4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPT4
Official Full Name: proteasome regulatory particle base subunit RPT4
Primary source: SGD:S000005785
Locus tag: YOR259C
See related: AllianceGenome:SGD:S000005785; FungiDB:YOR259C; VEuPathDB:YOR259C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CRL13; PCS1; SUG2
Summary: Enables protein domain specific binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including ERAD pathway; positive regulation of transcription by RNA polymerase II; and proteasome regulatory particle assembly. Located in nucleus. Part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPT4 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (812395..813708, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that proteasome subunits Rpt1, Rpt4, Rpn8, Rpn12, Pre6, and Pre10 are recruited to GAL10 rapidly upon galactose induction.
Title: Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.
Rpt4p and Cdc48p can extract some substrates from the ER in an independent, not co-operative, manner.
Title: Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.
Rpt4 works independently of Cdc48p in the ER-cytosol dislocation of ricin A chain
Title: Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.
Cdc48 and Rpt4 have cooperative roles in dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates
Title: A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates.
The non-proteolytic requirement for the proteasomal Sug2 ATPase includes at least the heat and oxidative stress-responsive genes.
Title: The proteasomal ATPase complex is required for stress-induced transcription in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome regulatory particle base subunit RPT4

NP_014902.3

ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

812395..813708 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183678.3 → NP_014902.3 TPA: proteasome regulatory particle base subunit RPT4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014902.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2W0, P53549, Q08718

UniProtKB/TrEMBL

A6ZP97, B3LJS7, C7GWD0, C8ZH10, G2WNC7, N1NWV8

Conserved Domains (1) summary

COG1222
Location:43 → 435

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]