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    SMP1 Smp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852480, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMP1
    Official Full Name
    Smp1p
    Primary source
    SGD:S000000386
    Locus tag
    YBR182C
    See related
    AllianceGenome:SGD:S000000386; FungiDB:YBR182C; VEuPathDB:YBR182C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA binding activity, bending and sequence-specific DNA binding activity. Involved in cellular response to osmotic stress and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language. Orthologous to several human genes including BORCS8-MEF2B (BORCS8-MEF2B readthrough); MEF2A (myocyte enhancer factor 2A); and MEF2B (myocyte enhancer factor 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SMP1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (593506..594864, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Dtr1p Neighboring gene ribosomal 40S subunit protein S6B Neighboring gene uncharacterized protein Neighboring gene phytoceramidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase. de Nadal E, et al. Mol Cell Biol, 2003 Jan. PMID 12482976, Free PMC Article
    2. MADS-box transcription factors adopt alternative mechanisms for bending DNA. West AG, et al. J Mol Biol, 1999 Mar 12. PMID 10064699
    3. The Saccharomyces cerevisiae MADS-box transcription factor Rlm1 is a target for the Mpk1 mitogen-activated protein kinase pathway. Dodou E, et al. Mol Cell Biol, 1997 Apr. PMID 9121433, Free PMC Article
    4. Improving ethanol yields in sugarcane molasses fermentation by engineering the high osmolarity glycerol pathway while maintaining osmotolerance in Saccharomyces cerevisiae. Jagtap RS, et al. Appl Microbiol Biotechnol, 2019 Jan. PMID 30488283
    5. Identification of multiple interacting alleles conferring low glycerol and high ethanol yield in Saccharomyces cerevisiae ethanolic fermentation. Hubmann G, et al. Biotechnol Biofuels, 2013 Jun 11. PMID 23759206, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smp1p
    NP_009741.3
    • MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      593506..594864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178530.3 → NP_009741.3  TPA: Smp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009741.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQH6, P38128
      UniProtKB/TrEMBL
      G2W9I3, N1P8L9
      Conserved Domains (2) summary
      COG5068
      Location:130 → 452
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:2 → 74
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38128.1

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