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    SGN1 Sgn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SGN1
    Official Full Name
    Sgn1p
    Primary source
    SGD:S000001440
    Locus tag
    YIR001C
    See related
    AllianceGenome:SGD:S000001440; FungiDB:YIR001C; VEuPathDB:YIR001C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RBP1; RBP29
    Summary
    Enables poly(A) binding activity. Involved in mRNA metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1L (PABPN1 like, cytoplasmic) and PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SGN1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (356143..356895, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene phosphoinositide 5-phosphatase INP51 Neighboring gene uncharacterized protein Neighboring gene 3'-5' DNA helicase Neighboring gene Aim21p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision. Gaspary A, et al. J Cell Biol, 2023 Nov 6. PMID 37638885, Free PMC Article
    2. The Saccharomyces cerevisiae RNA-binding protein Rbp29 functions in cytoplasmic mRNA metabolism. Winstall E, et al. J Biol Chem, 2000 Jul 21. PMID 10764794
    3. NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5. Ginsburg DS, et al. Mol Cell Biol, 2009 Dec. PMID 19822662, Free PMC Article
    4. yRACK1/Asc1 proxiOMICs-Towards Illuminating Ships Passing in the Night. Schmitt K, et al. Cells, 2019 Nov 4. PMID 31689955, Free PMC Article
    5. Method for identifying phosphorylated substrates of specific cyclin/cyclin-dependent kinase complexes. Li Y, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049391, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision.
      Title: Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA metabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sgn1p
    NP_012266.1
    • Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      356143..356895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179523.1 → NP_012266.1  TPA: Sgn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012266.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVT1, P40561
      UniProtKB/TrEMBL
      A6ZVR9, B3LTK8, C7GJH1, C8ZAQ0, G2WGE7, N1P0Q0
      Conserved Domains (2) summary
      COG0724
      Location:16 → 248
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12306
      Location:65 → 137
      RRM_II_PABPs; RNA recognition motif in type II polyadenylate-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40561.1

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