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    TPM1 tropomyosin TPM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TPM1
    Official Full Name
    tropomyosin TPM1
    Primary source
    SGD:S000005023
    Locus tag
    YNL079C
    See related
    AllianceGenome:SGD:S000005023; FungiDB:YNL079C; VEuPathDB:YNL079C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables actin lateral binding activity. Involved in actin cytoskeleton organization; cellular hyperosmotic response; and pseudohyphal growth. Located in actin filament bundle and cellular bud neck contractile ring. Is active in actin filament. Human ortholog(s) of this gene implicated in congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Orthologous to human TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TPM1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (478566..479165, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative mitochondrial 37S ribosomal protein SWS2 Neighboring gene Eos1p Neighboring gene Nis1p Neighboring gene Apj1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Push and pull of tropomyosin's opposite effects on myosin attachment to actin. A chimeric tropomyosin host-guest study. Ali LF, et al. Biochemistry, 2010 Dec 28. PMID 21114337, Free PMC Article
    2. A Novel Actin Binding Drug with In Vivo Efficacy. Ravichandran A, et al. Antimicrob Agents Chemother, 2019 Jan. PMID 30323040, Free PMC Article
    3. Site-specific amino-terminal mutants of yeast-expressed beta-actin. Characterization of the interaction with myosin and tropomyosin. Aspenström P, et al. FEBS Lett, 1992 May 25. PMID 1534298
    4. Modulation of myosin function by isoform-specific properties of Saccharomyces cerevisiae and muscle tropomyosins. Strand J, et al. J Biol Chem, 2001 Sep 14. PMID 11457840
    5. Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton. Liu HP, et al. Cell, 1989 Apr 21. PMID 2649250

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myo2p is not processive on bare actin but highly processive on actin-tropomyosin. Tpm1p supports the most robust processivity.
      Title: Tropomyosin is essential for processive movement of a class V myosin from budding yeast.
    2. Results show that yeast cofilin 1 can efficiently depolymerize and sever yeast actin filaments decorated with either tropomyosin (Tpm)1 or mouse tropomyosins TM1 and TM4.
      Title: Intrinsic capability of budding yeast cofilin to promote turnover of tropomyosin-bound actin filaments.
    3. Ultra short yeast tropomyosins show novel myosin regulation
      Title: Ultra short yeast tropomyosins show novel myosin regulation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin lateral binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tropomyosin TPM1
    NP_014320.1
    • Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      478566..479165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182917.1 → NP_014320.1  TPA: tropomyosin TPM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1A0, P17536, Q45TY1
      UniProtKB/TrEMBL
      A6ZS01, B3LNT8, C7GUM9, C8ZGF1, G2WM25, N1NXI5
      Conserved Domains (1) summary
      pfam12718
      Location:7 → 186
      Tropomyosin_1; Tropomyosin like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17536.1

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