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    SCM4 Scm4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCM4
    Official Full Name
    Scm4p
    Primary source
    SGD:S000003281
    Locus tag
    YGR049W
    See related
    AllianceGenome:SGD:S000003281; FungiDB:YGR049W; VEuPathDB:YGR049W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in autophagy of mitochondrion and macroautophagy. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SCM4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (591314..591877)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription factor TFIIIC subunit TFC4 Neighboring gene polyubiquitin-binding protein UFD1 Neighboring gene uncharacterized protein Neighboring gene protein kinase FMP48

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SCM4, a gene that suppresses mutant cdc4 function in budding yeast. Smith SA, et al. Mol Gen Genet, 1992 Nov. PMID 1465103
    2. The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. Becker T, et al. J Cell Biol, 2011 Aug 8. PMID 21825073, Free PMC Article
    3. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
    4. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Zahedi RP, et al. Mol Biol Cell, 2006 Mar. PMID 16407407, Free PMC Article
    5. MitoStores: chaperone-controlled protein granules store mitochondrial precursors in the cytosol. Krämer L, et al. EMBO J, 2023 Apr 3. PMID 36704946, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Scm4p
    NP_011563.1
    • Mitochondrial outer membrane hypothetical protein; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      591314..591877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181178.1 → NP_011563.1  TPA: Scm4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUI6, P32564, Q45U35
      UniProtKB/TrEMBL
      A6ZV36, B3LIH2, C7GXN4, C8Z8U4, G2WED8, N1P3H4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32564.1

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