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    bub3 mitotic spindle checkpoint WD repeat protein Bub3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541856, updated on 18-Sep-2024

    Summary

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    Official Symbol
    bub3
    Official Full Name
    mitotic spindle checkpoint WD repeat protein Bub3
    Primary source
    PomBase:SPAC23H3.08c
    Locus tag
    SPOM_SPAC23H3.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See bub3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (2506085..2507369, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene AP-3 adaptor complex subunit Apl6 Neighboring gene ncRNA Neighboring gene mitochondrial 37S ribosomal protein uS14m Neighboring gene threonine aldolase Gly1 Neighboring gene ncRNA Neighboring gene tRNA-Cys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation. Tange Y, et al. Genetics, 2008 Jun. PMID 18505884, Free PMC Article
    2. Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin. Windecker H, et al. EMBO Rep, 2009 Sep. PMID 19680287, Free PMC Article
    3. The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function. Kadura S, et al. Mol Biol Cell, 2005 Jan. PMID 15525673, Free PMC Article
    4. Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p. Vanoosthuyse V, et al. Mol Cell Biol, 2004 Nov. PMID 15509783, Free PMC Article
    5. Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe. Pascual-Ortiz M, et al. Mol Cell Biol, 2018 May 1. PMID 29440310, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spindle checkpoint proteins are severely depleted from unattached kinetochores in fission yeast cells lacking Bub3p.
      Title: Bub3p facilitates spindle checkpoint silencing in fission yeast.
    2. find that Bub3 is also dispensable for shugoshin localization to the centromeres, which is the second known function of Bub1.
      Title: Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin.
    3. the bub3 mutation only weakly affected the stability of minichromosome Ch16 compared with other spindle assembly checkpoint mutants
      Title: Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation.
    4. Bub1p-A78V is defective in both nuclear accumulation and kinetochore targeting; a threshold level of nuclear Bub1p is necessary for the nuclear accumulation of Bub3p and Mad3p
      Title: The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic metaphase chromosome recapture IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of bub1-bub3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of bub1-bub3 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitotic spindle checkpoint WD repeat protein Bub3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2506085..2507369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019227.3 → NP_593798.1  mitotic spindle checkpoint WD repeat protein Bub3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593798.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42860
      Conserved Domains (3) summary
      COG2319
      Location:8 → 294
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:15 → 54
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:8 → 291
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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