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    PRY2 sterol-binding protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRY2
    Official Full Name
    sterol-binding protein
    Primary source
    SGD:S000001721
    Locus tag
    YKR013W
    See related
    AllianceGenome:SGD:S000001721; FungiDB:YKR013W; VEuPathDB:YKR013W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YFW12
    Summary
    Enables sterol binding activity. Involved in fatty acid transport and sterol transport. Located in extracellular region. Orthologous to several human genes including GLIPR2 (GLI pathogenesis related 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRY2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (463959..464948)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Tof2p Neighboring gene chromatin-associated RNAPIII regulator FPT1 Neighboring gene Rab family GTPase YPT52 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes. Wei YF, et al. J Bacteriol, 1995 Sep. PMID 7665478, Free PMC Article
    2. The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain. Cottier S, et al. Biol Open, 2020 Jul 2. PMID 32554483, Free PMC Article
    3. Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. Choudhary V, et al. Proc Natl Acad Sci U S A, 2012 Oct 16. PMID 23027975, Free PMC Article
    4. The pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is a fatty acid-binding protein. Darwiche R, et al. J Biol Chem, 2017 May 19. PMID 28365570, Free PMC Article
    5. Prostate secretory protein 94 inhibits sterol binding and export by the mammalian CAP protein CRISP2 in a calcium-sensitive manner. El Atab O, et al. J Biol Chem, 2022 Mar. PMID 35063506, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    sterol-binding protein
    NP_012938.3
    • Sterol binding protein involved in the export of acetylated sterols; role in sterol export is redundant with that of PRY1; redundant role with PRY1 and PRY3 in the export of free fatty acids; may be involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      463959..464948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179803.3 → NP_012938.3  TPA: sterol-binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012938.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX78, P36110
      UniProtKB/TrEMBL
      A6ZZX7, B3LR97, B5VMG0, C7GNP5, C8ZCH8, N1P2M3
      Conserved Domains (1) summary
      cd05384
      Location:191 → 319
      CAP_PRY1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36110.1

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