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    set2 histone lysine H3-K36 methyltransferase Set2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542070, updated on 18-Sep-2024

    Summary

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    Official Symbol
    set2
    Official Full Name
    histone lysine H3-K36 methyltransferase Set2
    Primary source
    PomBase:SPAC29B12.02c
    Locus tag
    SPOM_SPAC29B12.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    kmt3
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    Genomic context

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    See set2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5408180..5411065, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene SNF2 family ATP-dependent chromatin remodeller Ino80 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A. Lim KK, et al. Nucleic Acids Res, 2024 May 8. PMID 38442274, Free PMC Article
    2. Bub1 kinase- and H2A phosphorylation-independent regulation of Shugoshin proteins under glucose-restricted conditions. Kobayashi Y, et al. Sci Rep, 2019 Feb 26. PMID 30809004, Free PMC Article
    3. Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Morris SA, et al. Eukaryot Cell, 2005 Aug. PMID 16087749, Free PMC Article
    4. Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription. Pai CC, et al. Cell Rep, 2017 Sep 12. PMID 28903048, Free PMC Article
    5. Cell cycle control of centromeric repeat transcription and heterochromatin assembly. Chen ES, et al. Nature, 2008 Feb 7. PMID 18216783

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A.
      Title: Set2 regulates Ccp1 and Swc2 to ensure centromeric stability by retargeting CENP-A.
    2. Bub1 kinase- and H2A phosphorylation-independent regulation of Shugoshin proteins under glucose-restricted conditions.
      Title: Bub1 kinase- and H2A phosphorylation-independent regulation of Shugoshin proteins under glucose-restricted conditions.
    3. A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
      Title: A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
    4. A novel role for Set2 and histone H3 lysine methylation in coordinating the recruitment of DNA repair machineries to timely manage alkylating damage.Set2 is epistatic with DNA damage checkpoint factors and regulates the checkpoint effector, Chk1.
      Title: Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast.
    5. Set2-dependent H3K36 methylation reduces chromatin accessibility, reduces resection and promotes non-homologous end joining DNA repair.
      Title: A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables histone H3K36 dimethyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone H3K36 dimethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 trimethyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone H3K36 trimethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone lysine H3-K36 methyltransferase Set2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5408180..5411065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020411.3 → NP_594980.1  histone lysine H3-K36 methyltransferase Set2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594980.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14026
      Conserved Domains (6) summary
      smart00570
      Location:125 → 179
      AWS; associated with SET domains
      smart00317
      Location:180 → 303
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:304 → 320
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:275 → 791
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam08236
      Location:699 → 771
      SRI; SRI (Set2 Rpb1 interacting) domain
      pfam08711
      Location:440 → 489
      Med26; TFIIS helical bundle-like domain
    Nucleotide Protein
    Heading Accession and Version

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