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    pik1 Golgi-specific 1-phosphatidylinositol 4-kinase, type III-beta Pik1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541887, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pik1
    Official Full Name
    Golgi-specific 1-phosphatidylinositol 4-kinase, type III-beta Pik1
    Primary source
    PomBase:SPAC22E12.16c
    Locus tag
    SPOM_SPAC22E12.16C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pik1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (5049155..5052408, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase S6K family Sck2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ARF GTPase-activating protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesis. Willet AH, et al. J Cell Sci, 2023 Nov 1. PMID 37815455, Free PMC Article
    2. Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1. Sugihara A, et al. Biochem Biophys Res Commun, 2018 Feb 19. PMID 29410177
    3. Structure of a Ca2+-myristoyl switch protein that controls activation of a phosphatidylinositol 4-kinase in fission yeast. Lim S, et al. J Biol Chem, 2011 Apr 8. PMID 21288895, Free PMC Article
    4. Cdc4p, a contractile ring protein essential for cytokinesis in Schizosaccharomyces pombe, interacts with a phosphatidylinositol 4-kinase. Desautels M, et al. J Biol Chem, 2001 Feb 23. PMID 11087749
    5. A calmodulin-related light chain from fission yeast that functions with myosin-I and PI 4-kinase. Sammons MR, et al. J Cell Sci, 2011 Jul 15. PMID 21693583

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in mitotic cytokinesis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus HDA PubMed 
    NOT is_active_in cell division site EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgi-specific 1-phosphatidylinositol 4-kinase, type III-beta Pik1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5049155..5052408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020271.3 → NP_594842.1  Golgi-specific 1-phosphatidylinositol 4-kinase, type III-beta Pik1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594842.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10366
      UniProtKB/TrEMBL
      C5IGP5, C5IGP6, C5IGP7
      Conserved Domains (4) summary
      COG5032
      Location:1 → 851
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05168
      Location:549 → 851
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
      pfam11522
      Location:110 → 160
      Pik1; Yeast phosphatidylinositol-4-OH kinase Pik1
      cl00271
      Location:29 → 103
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    Nucleotide Protein
    Heading Accession and Version

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