U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SRO77 putative Rab GTPase-binding protein SRO77 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852168, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SRO77
    Official Full Name
    putative Rab GTPase-binding protein SRO77
    Primary source
    SGD:S000000202
    Locus tag
    YBL106C
    See related
    AllianceGenome:SGD:S000000202; FungiDB:YBL106C; VEuPathDB:YBL106C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SNI2; SOP2
    Summary
    Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in Golgi to plasma membrane transport and exocytosis. Located in plasma membrane. Orthologous to several human genes including LLGL1 (LLGL scribble cell polarity complex component 1); LLGL2 (LLGL scribble cell polarity complex component 2); and STXBP5L (syntaxin binding protein 5L). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SRO77 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (10847..13879, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene Mix23p Neighboring gene protein kinase C Neighboring gene Sea4p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Complementation of temperature tolerance by rat Rgl-1 recessive oncogene in the absence of Saccharomyces cerevisiae Sop genes. Kim YK, et al. Oncol Rep, 2004 Nov. PMID 15492800
    2. Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress. Wadskog I, et al. Mol Biol Cell, 2004 Mar. PMID 14718573, Free PMC Article
    3. Disruption of protein-protein interaction in the Mgl-1 oncoprotein. Kim YS, et al. Oncol Rep, 2006 Oct. PMID 16969496
    4. Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene. Kim YS, et al. Int J Oncol, 2003 Dec. PMID 14612921
    5. WD-40 repeat containing rat lethal giant larvae recessive oncogene, but not m-tomosyn, restores the salt sensitivity in Saccharomyces cerevisiae. Kim YS, et al. Int J Oncol, 2003 Jul. PMID 12792798

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggested that the tumour suppressor homologue SRO7/SRO77 regulated cell proliferation and yeast colony development via the Rho1-Tor1 pathway.
      Title: Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables myosin II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative Rab GTPase-binding protein SRO77
    NP_009444.2
    • Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; interacts with SNARE protein Sec9p; homolog of Drosophila lethal giant larvae tumor suppressor; SRO77 has a paralog, SRO7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      10847..13879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178346.2 → NP_009444.2  TPA: putative Rab GTPase-binding protein SRO77 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009444.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPP7, P38163
      UniProtKB/TrEMBL
      B5VDN9, C7GSD9, N1P8F1
      Conserved Domains (3) summary
      sd00039
      Location:88 → 122
      7WD40; WD40 repeat [structural motif]
      pfam08596
      Location:514 → 916
      Lgl_C; Lethal giant larvae(Lgl) like, C-terminal
      pfam17005
      Location:48 → 151
      WD40_like; WD40-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38163.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools