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    MSP1 Msp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852915, updated on 17-Dec-2024

    Summary

    Official Symbol
    MSP1
    Official Full Name
    Msp1p
    Primary source
    SGD:S000003260
    Locus tag
    YGR028W
    See related
    AllianceGenome:SGD:S000003260; FungiDB:YGR028W; VEuPathDB:YGR028W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YTA4
    Summary
    Predicted to enable ATP hydrolysis activity. Involved in protein targeting to mitochondrion. Located in mitochondrial outer membrane and peroxisomal membrane. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MSP1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (542203..543291)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Glu Neighboring gene flavin-linked sulfhydryl oxidase Neighboring gene tRNA-Asp

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane PubMed 
    is_active_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrial outer membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in peroxisomal membrane PubMed 
    located_in peroxisomal membrane  
    located_in peroxisome  

    General protein information

    Preferred Names
    Msp1p
    NP_011542.3
    • Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; ATP-driven extractase that pulls mislocalized tail-anchored proteins into the cytosol, passing them to the GET pathway for transfer to the ER membrane for degradation, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      542203..543291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181157.3 → NP_011542.3  TPA: Msp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011542.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUG3, P28737
      UniProtKB/TrEMBL
      A6ZV16, B3LIJ2, B5VIY8, C7GK95, C8Z8S2, G2WEB8, N1P3F5
      Conserved Domains (3) summary
      COG5271
      Location:10 → 164
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam17862
      Location:280 → 319
      AAA_lid_3; AAA+ lid domain
      cd19520
      Location:92 → 255
      RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains
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