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    DFB DHFS-FPGS homolog B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830484, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DFB
    Official Full Name
    DHFS-FPGS homolog B
    Primary source
    TAIR:AT5G05980
    Locus tag
    AT5G05980
    See related
    Araport:AT5G05980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATDFB; DHFS-FPGS homolog B; folylpolyglutamate synthetase 1; FPGS1; K18J17.17; K18J17_17
    Summary
    Encodes one of the three folylpolyglutamate synthetase isoforms (FPGSs): FPGS1 (At5g05980, plastidic), FPGS2 (At3g10160, mitochondrial) and FPGS3 (At3g55630, cytosolic).
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    Genomic context

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    See DFB in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Sequence:
    Chromosome: 5; NC_003076.8 (1799490..1804492, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene maternal effect embryo arrest 60 Neighboring gene cell wall RBR3-like protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene prenylated RAB acceptor 1.A2 Neighboring gene Mitochondrial glycoprotein family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness. Meng H, et al. Biochem Biophys Res Commun, 2017 Jan 8. PMID 27845046
    2. The plastidial folylpolyglutamate synthetase and root apical meristem maintenance. Srivastava AC, et al. Plant Signal Behav, 2011 May. PMID 21502816, Free PMC Article
    3. Combining loss of function of FOLYLPOLYGLUTAMATE SYNTHETASE1 and CAFFEOYL-COA 3-O-METHYLTRANSFERASE1 for lignin reduction and improved saccharification efficiency in Arabidopsis thaliana. Xie H, et al. Biotechnol Biofuels, 2019. PMID 31073332, Free PMC Article
    4. The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis. Srivastava AC, et al. Plant Physiol, 2011 Mar. PMID 21233333, Free PMC Article
    5. Folate polyglutamylation is involved in chromatin silencing by maintaining global DNA methylation and histone H3K9 dimethylation in Arabidopsis. Zhou HR, et al. Plant Cell, 2013 Jul. PMID 23881414, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, these results indicated that intact folate metabolism was necessary for nitrogen metabolism in Arabidopsis thaliana under nitrate-limited condition in darkness, providing novel insights into function of folate.
      Title: Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness.
    2. Data indicates that intact folate metabolism was necessary for nitrogen metabolism in Arabidopsis thaliana under nitrate-limited condition in darkness.
      Title: Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness.
    3. Data indicate that H3K9 dimethylation level in mutants ros1 fpgs1 (folylpolyglutamate synthase 1) was clearly reduced.
      Title: Folate polyglutamylation is involved in chromatin silencing by maintaining global DNA methylation and histone H3K9 dimethylation in Arabidopsis.
    4. Mutants in the AtDFB (At5G05980) gene disrupt primary root development in Arabidopsis thaliana seedlings.
      Title: The plastidial folylpolyglutamate synthetase and root apical meristem maintenance.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001036763.2
    NM_120680.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables tetrahydrofolylpolyglutamate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables tetrahydrofolylpolyglutamate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lignin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within one-carbon metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within quiescent center organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tetrahydrofolylpolyglutamate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DHFS-FPGS homolog B
    NP_001031840.1
    • DHFS-FPGS homolog B (DFB); CONTAINS InterPro DOMAIN/s: Folylpolyglutamate synthetase, conserved site (InterPro:IPR018109), Mur ligase, central (InterPro:IPR013221), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog D (TAIR:AT3G55630.3); Has 7710 Blast hits to 7708 proteins in 2543 species: Archae - 43; Bacteria - 4850; Metazoa - 165; Fungi - 360; Plants - 132; Viruses - 0; Other Eukaryotes - 2160 (source: NCBI BLink).
    NP_196217.2
    • DHFS-FPGS homolog B (DFB); CONTAINS InterPro DOMAIN/s: Folylpolyglutamate synthetase, conserved site (InterPro:IPR018109), Mur ligase, central (InterPro:IPR013221), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog D (TAIR:AT3G55630.3); Has 7626 Blast hits to 7624 proteins in 2505 species: Archae - 43; Bacteria - 4775; Metazoa - 165; Fungi - 350; Plants - 132; Viruses - 0; Other Eukaryotes - 2161 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1799490..1804492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120680.3 → NP_196217.2  DHFS-FPGS homolog B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DH96, F4K2A1, F4K2A2, Q8W040, Q9FI88
      UniProtKB/TrEMBL
      A0A178URZ6
      Conserved Domains (1) summary
      PLN02881
      Location:54 → 571
      PLN02881; tetrahydrofolylpolyglutamate synthase

    2. NM_001036763.2 → NP_001031840.1  DHFS-FPGS homolog B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y247
      Conserved Domains (1) summary
      PLN02881
      Location:1 → 513
      PLN02881; tetrahydrofolylpolyglutamate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4K2A1.1

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