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    RPL42A ribosomal 60S subunit protein L42A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL42A
    Official Full Name
    ribosomal 60S subunit protein L42A
    Primary source
    SGD:S000005106
    Locus tag
    YNL162W
    See related
    AllianceGenome:SGD:S000005106; FungiDB:YNL162W; VEuPathDB:YNL162W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPL36A (ribosomal protein L36a) and RPL36AL (ribosomal protein L36a like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL42A in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    2
    Sequence:
    Chromosome: XIV; NC_001146.8 (331322..332154)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene GTPase RIA1 Neighboring gene uncharacterized protein Neighboring gene serine/threonine protein kinase CBK1 Neighboring gene Ygp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Site saturation mutagenesis of ribosomal protein L42 at 56th residue and application as a consecutive selection marker for cycloheximide resistance in yeast. Bae JH, et al. FEMS Microbiol Lett, 2018 Apr 1. PMID 29566228
    2. The primary structure of protein 44 from the large subunit of yeast ribosomes. Itoh T, et al. FEBS Lett, 1978 Dec 15. PMID 365584
    3. Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome. Pellegrino S, et al. Nucleic Acids Res, 2019 Apr 8. PMID 30759226, Free PMC Article
    4. Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis. Malyutin AG, et al. EMBO J, 2017 Apr 3. PMID 28179369, Free PMC Article
    5. mRNA with Mammalian Codon Bias Accumulates in Yeast Mutants with Constitutive Stress Granules. Kozlova NV, et al. Int J Mol Sci, 2020 Feb 12. PMID 32059599, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The 56th residue of(Rpl42a determines the sensitivity of yeast cells to the antibiotic cycloheximide.
      Title: Site saturation mutagenesis of ribosomal protein L42 at 56th residue and application as a consecutive selection marker for cycloheximide resistance in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cycloheximide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L42A
    NP_014237.2
    • Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42A has a paralog, RPL42B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      331322..332154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183000.1 → NP_014237.2  TPA: ribosomal 60S subunit protein L42A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014237.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL90, P02405, P0CX27, P0CX28
      UniProtKB/TrEMBL
      A6ZRS2, B3LP17, C8Z9T8, G2WFL4, N1P172
      Conserved Domains (1) summary
      PTZ00157
      Location:1 → 86
      PTZ00157; 60S ribosomal protein L36a; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX27.1
    P0CX28.1

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