Marchf5 membrane associated ring-CH-type finger 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Marchf5provided by MGI
Official Full Name: membrane associated ring-CH-type finger 5provided by MGI
Primary source: MGI:MGI:1915207
See related: Ensembl:ENSMUSG00000023307 AllianceGenome:MGI:1915207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MITOL; March5; Marchv; Rnf153; MARCH-V; 1810015H18Rik; 2310008I22Rik; 2700055A20Rik; 5730499H23Rik; E130202O05Rik
Summary: Predicted to enable GTPase binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of mitochondrial fission; protein localization to mitochondrion; and protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human MARCHF5 (membrane associated ring-CH-type finger 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 15.2), CNS E14 (RPKM 13.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 32.2 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (37184939..37201856)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (37207540..37224457)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response.
Title: MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response.
PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
Title: PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling.
Title: Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling.
MARCH5 promotes STING pathway activation by suppressing polymer formation of oxidized STING.
Title: MARCH5 promotes STING pathway activation by suppressing polymer formation of oxidized STING.
Mitochondrial E3 ubiquitin ligase MARCH5 is required for mouse oocyte meiotic maturationdagger.
Title: Mitochondrial E3 ubiquitin ligase MARCH5 is required for mouse oocyte meiotic maturation†.
Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-beta oligomer generation.
Title: Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation.
A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis.
Title: A potent protective effect of baicalein on liver injury by regulating mitochondria-related apoptosis.
MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia.
Title: MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia.
Results showed that mitochondrial abnormalities in MITOL KO brain induced mild behavioral changes. MITOL KO brain also displayed enhanced oxidative stress, which may result from increased electron leakage from mitochondria. The reduced ER-mitochondria tethering and excessive mitochondrial fission may trigger neuroinflammation through oxidative stress.
Title: MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.
MARCH5 is regulated by peroxisome proliferator-activated receptor-gamma (PPARgamma) during adipogenesis and is correlated with fat mass across a panel of genetically diverse mouse strains, in ob/ob mice, and in humans. Furthermore, manipulation of MARCH5 expression in vitro and in vivo alters mitochondrial function, affects cellular metabolism, and leads to differential regulation of several metabolic genes
Title: The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

RH124321 (e-PCR)
- UniSTS:161143

NoName (e-PCR)
- UniSTS:490644

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of mitochondrial fission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MARCHF5

Names: E3 ubiquitin-protein ligase MARCH5; RING-type E3 ubiquitin transferase MARCH5; RING-type E3 ubiquitin transferase MARCHF5; membrane-associated RING finger protein 5; membrane-associated RING-CH protein V; membrane-associated ring finger (C3HC4) 5; ring finger protein 153

NP_001157808.1

EC 2.3.2.27

NP_001157809.1

EC 2.3.2.27

NP_001365726.1

EC 2.3.2.27

NP_001365727.1

EC 2.3.2.27

NP_081590.3

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164336.1 → NP_001157808.1 E3 ubiquitin-protein ligase MARCHF5 isoform 2

See identical proteins and their annotated locations for NP_001157808.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK007511, AK009364, BY070559, CX733941

Consensus CDS

CCDS50427.1

UniProtKB/TrEMBL

A0A0R4J1H0

Related

ENSMUSP00000108010.2, ENSMUST00000112391.8

Conserved Domains (1) summary

cd16701
Location:12 → 72

RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)
NM_001164337.1 → NP_001157809.1 E3 ubiquitin-protein ligase MARCHF5 isoform 3

See identical proteins and their annotated locations for NP_001157809.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC161238, AK007511, AK009364, AK021403, BY070559

Conserved Domains (1) summary

smart00744
Location:14 → 69

RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
NM_001378797.1 → NP_001365726.1 E3 ubiquitin-protein ligase MARCHF5 isoform 4

Status: VALIDATED

Source sequence(s)

AC161238

Conserved Domains (1) summary

cd16701
Location:12 → 72

RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)
NM_001378798.1 → NP_001365727.1 E3 ubiquitin-protein ligase MARCHF5 isoform 5

Status: VALIDATED

Source sequence(s)

AC161238
NM_027314.3 → NP_081590.3 E3 ubiquitin-protein ligase MARCHF5 isoform 1

See identical proteins and their annotated locations for NP_081590.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC161238, AK003478, AK009364, AK017741, BC132455, BY070559

Consensus CDS

CCDS29776.1

UniProtKB/Swiss-Prot

Q3KNM2, Q3KNM3, Q6P230, Q9CPS3, Q9CTI6

UniProtKB/TrEMBL

A2RTC8

Related

ENSMUSP00000024078.8, ENSMUST00000024078.15

Conserved Domains (1) summary

cd16701
Location:12 → 72

RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)