Pabir1 PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pabir1provided by MGI
Official Full Name: PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1provided by MGI
Primary source: MGI:MGI:1915284
See related: Ensembl:ENSMUSG00000074922 AllianceGenome:MGI:1915284
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm9849; Fam122a; 2410124L17Rik; 2900009I07Rik
Summary: Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in mitotic G2/M transition checkpoint; positive regulation of cell growth; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo. Orthologous to human PABIR1 (PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 19 B; 19 19.53 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (24451270..24454819, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (24475779..24477474, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.
Title: FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase 2A binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitotic G2/M transition checkpoint	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: P2R1A-PPP2R2A-interacting phosphatase regulator 1

Names: PABIR family member 1; family with sequence similarity 122, member A; protein FAM122A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.