Shc SHC-adaptor protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Shcprovided by FlyBase
Official Full Name: SHC-adaptor proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0015296
Locus tag: Dmel_CG3715
See related: AllianceGenome:FB:FBgn0015296
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3715; D-Shc; Dmel\CG3715; dshc; dShc; DSHC; shc
Summary: Enables epidermal growth factor receptor binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; epithelial cell migration; and regionalization. Predicted to be active in plasma membrane. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including SHC1 (SHC adaptor protein 1) and SHC3 (SHC adaptor protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67B5-67B5; 3-29 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9427010..9428671)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9420110..9421771)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pTyr 1227(YD) Neu (ErbB-2) autophosphorylation site signal requires Shc.
Title: Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification, ovarian follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal region determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SHC-adaptor protein

Names: CG3715-PA; SHC adaptor protein; Shc-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9427010..9428671

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079944.3 → NP_524683.2 SHC-adaptor protein [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524683.2

Status: REVIEWED

UniProtKB/TrEMBL

Q24080, Q6NPB1, Q9V3C8

Related

FBpp0076186

Conserved Domains (2) summary

cd09925
Location:293 → 396

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:19 → 178

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain