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    CG42674 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42674provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261556
    Locus tag
    Dmel_CG42674
    See related
    AllianceGenome:FB:FBgn0261556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13811; CG13812; CG32223; CG42348; CG7323; Dmel\CG42674
    Old locus tag
    Dmel_CG13811; Dmel_CG32223; Dmel_CG42348; Dmel_CG7323
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Is expressed in leg and organism. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to several human genes including PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42674 in Genome Data Viewer
    Location:
    76F2-77A1; 3-47 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20149614..20198317, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20142714..20191417, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene gigas Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45942 Neighboring gene Snakeskin Neighboring gene uncharacterized protein Neighboring gene obstructor-F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila. Yanagihashi Y, et al. J Cell Sci, 2012 Apr 15. PMID 22328496
    2. Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair. Nakamura M, et al. J Cell Biol, 2017 Dec 4. PMID 28923977, Free PMC Article
    3. Parallel and population-specific gene regulatory evolution in cold-adapted fly populations. Huang Y, et al. Genetics, 2021 Jul 14. PMID 33989401, Free PMC Article
    4. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. Greenberg L, et al. Mech Dev, 2011 Jan-Feb. PMID 20851182, Free PMC Article
    5. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42674-PA
    CG42674-PB
    CG42674-PC
    CG42674-PD
    CG42674-PE
    CG42674-PF
    CG42674-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20149614..20198317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275161.1 → NP_001262090.1  uncharacterized protein Dmel_CG42674, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262090.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFQ9
      Conserved Domains (2) summary
      cd13244
      Location:1057 → 1152
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:813 → 999
      RhoGEF; RhoGEF domain

    2. NM_001144514.3 → NP_001137986.1  uncharacterized protein Dmel_CG42674, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z086
      Conserved Domains (2) summary
      cd13244
      Location:1090 → 1185
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:846 → 1032
      RhoGEF; RhoGEF domain

    3. NM_001202208.2 → NP_001189137.1  uncharacterized protein Dmel_CG42674, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFQ9
      Conserved Domains (2) summary
      cd13244
      Location:1057 → 1152
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:813 → 999
      RhoGEF; RhoGEF domain

    4. NM_001144513.3 → NP_001137985.1  uncharacterized protein Dmel_CG42674, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z087
      Conserved Domains (2) summary
      cd13244
      Location:1090 → 1185
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:846 → 1032
      RhoGEF; RhoGEF domain

    5. NM_001144512.3 → NP_001137984.1  uncharacterized protein Dmel_CG42674, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137984.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z088
      Conserved Domains (2) summary
      cd13244
      Location:1271 → 1366
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:1027 → 1213
      RhoGEF; RhoGEF domain

    6. NM_140925.6 → NP_649182.4  uncharacterized protein Dmel_CG42674, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649182.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW85
      Conserved Domains (2) summary
      cd13244
      Location:1271 → 1366
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:1027 → 1213
      RhoGEF; RhoGEF domain

    7. NM_001275162.1 → NP_001262091.1  uncharacterized protein Dmel_CG42674, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG56
      Conserved Domains (2) summary
      cd13244
      Location:493 → 588
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:249 → 435
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z086 B7Z086
    B7Z087 B7Z087
    B7Z088 B7Z088
    M9PFQ9 M9PFQ9
    M9PG56 M9PG56
    Q8SWY9 Q8SWY9
    Q95R62 Q95R62
    Q9VW85 Q9VW85

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