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    unc80 uncoordinated 80 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc80provided by FlyBase
    Official Full Name
    uncoordinated 80provided by FlyBase
    Primary source
    FLYBASE:FBgn0039536
    Locus tag
    Dmel_CG18437
    See related
    AllianceGenome:FB:FBgn0039536
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18437; Dmel\CG18437; Dunc80; UNC80
    Summary
    Predicted to enable monoatomic cation channel activity. Involved in locomotor rhythm. Part of cation channel complex. Is expressed in adult head and spermatozoon. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unc80 in Genome Data Viewer
    Location:
    98A15-98B1; 3-94 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27662439..27677099)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23488161..23502821)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tau Neighboring gene Ribosomal protein S10a Neighboring gene Myosin alkali light chain 1 Neighboring gene Hydroxysteroid dehydrogenase like 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79. Murakami K, et al. G3 (Bethesda), 2021 Aug 7. PMID 34849820, Free PMC Article
    2. UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila. Lear BC, et al. PLoS One, 2013. PMID 24223770, Free PMC Article
    3. New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN. Monteil A, et al. Physiol Rev, 2024 Jan 1. PMID 37615954
    4. A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Flourakis M, et al. Cell, 2015 Aug 13. PMID 26276633, Free PMC Article
    5. Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals. Ghezzi A, et al. Front Mol Neurosci, 2014. PMID 24639627, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NA, UNC79, and UNC80 function together in circadian clock neurons to promote rhythmic behavior.
      Title: UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cation channel complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cation channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncoordinated 80
    Names
    CG18437-PC
    CG18437-PD
    CG18437-PE
    CG18437-PF
    CG18437-PG
    unc80-PC
    unc80-PD
    unc80-PE
    unc80-PF
    unc80-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27662439..27677099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276095.1 → NP_001263024.1  uncoordinated 80, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHR1
      Conserved Domains (2) summary
      pfam15778
      Location:51 → 260
      UNC80; Cation channel complex component UNC80
      pfam17061
      Location:3069 → 3225
      PARM; PARM

    2. NM_001276094.1 → NP_001263023.1  uncoordinated 80, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH56
      Conserved Domains (2) summary
      pfam15778
      Location:51 → 260
      UNC80; Cation channel complex component UNC80
      pfam17061
      Location:3046 → 3202
      PARM; PARM

    3. NM_143320.4 → NP_651577.4  uncoordinated 80, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651577.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VB11
      Conserved Domains (2) summary
      pfam15778
      Location:51 → 260
      UNC80; Cation channel complex component UNC80
      pfam17061
      Location:3040 → 3196
      PARM; PARM

    4. NM_001276096.1 → NP_001263025.1  uncoordinated 80, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263025.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI46
      Conserved Domains (2) summary
      pfam15778
      Location:51 → 260
      UNC80; Cation channel complex component UNC80
      pfam17061
      Location:3040 → 3196
      PARM; PARM

    5. NM_001276093.1 → NP_001263022.1  uncoordinated 80, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHA4
      Conserved Domains (2) summary
      pfam15778
      Location:51 → 260
      UNC80; Cation channel complex component UNC80
      pfam17061
      Location:3016 → 3177
      PARM; PARM
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH56 A0A0B4KH56
    A0A0B4KHA4 A0A0B4KHA4
    A0A0B4KHR1 A0A0B4KHR1
    A0A0B4KI46 A0A0B4KI46
    Q9VB11.5 Q9VB11

    Gene LinkOut

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